Sfoglia per Autore
A causative link between the structure of aberrant protein oligomers and their toxicity
2010 S.Campioni;B.Mannini;M.Zampagni;A.Pensalfini;C.Parrini;E.Evangelisti;A.Relini;M.Stefani;C.M.Dobson;C.Cecchi;F.Chiti
Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action
2011 B. Mannini; S. Campioni; M. Boninsegna; E. Palagano; R. Cascella; M. Zampagni; A. Penco; M. Wilson; S. Meehan; C. Roodveldt; A. Relini; C. Cecchi; F. Chiti
Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils
2011 H.Ramshini; C.Parrini; A.Relini; M.Zampagni; B.Mannini; A.Pesce; A.A.Saboury; M.Nemat-Gorgani; F.Chiti
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells
2011 Zampagni M; Cascella R; Casamenti F; Grossi C; Evangelisti E; Wright D; Becatti M; Liguri G; Mannini B; Campioni S; Chiti F; Cecchi C.
The induction of α-helical structure in partially unfolded HypF-N does not affect its aggregation propensity
2011 B.Ahmad; I.Vigliotta; F.Tatini; S.Campioni; B.Mannini; J.Winkelmann; B.Tiribilli; F.Chiti
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
2012 B. Mannini; R. Cascella; M. Zampagni; M. van Waarde-Verhagen; S. Meehan; C. Roodveldt; S. Campioni; M. Boninsegna; A. Penco; A. Relini; H.H. Kampinga; C.M. Dobson; M.R. Wilson; C. Cecchi; F. Chiti
Salt anions promote the conversion of HypF-N into amyloid-like oligomers and modulate the structure of the oligomers and the monomeric precursor state.
2012 Campioni S;Mannini B;López-Alonso JP;Shalova IN;Penco A;Mulvihill E;Laurents DV;Relini A;Chiti F
Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action
2012 B. Mannini; S. Campioni; M. Boninsegna; A. Penco; R. Cascella; M. Zampagni; M. Wilson; S. Meehan; C. Roodveldt; C. Dobson; A. Relini; C. Cecchi; F. Chiti
Glycosaminoglycans (GAGs) Suppress the Toxicity of HypF-N Prefibrillar Aggregates
2012 T. Saridaki; M. Zampagni; B. Mannini; E. Evangelisti; N. Taddei; C. Cecchi; F. Chiti
Early-forming aberrant aggregates in protein deposition diseases: structural characteristics, interaction with molecular chaperones, ability to trigger inflammation
2013 Benedetta Mannini
Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity
2014 Mannini B; Mulvihill E; Sgromo C; Cascella R; Khodarahmi R; Ramazzotti M; Dobson CM; Cecchi C; and Chiti F
SERS Detection of Amyloid Oligomers on Metallorganic-Decorated Plasmonic Beads
2015 Guerrini, Luca; Arenal, Raul; Mannini, Benedetta; Chiti, Fabrizio; Pini, Roberto; Matteini, Paolo; Alvarez-Puebla, Ramon A
Bis(indolyl)phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme
2016 Ramshini, Hassan; Mannini, Benedetta; Khodayari, Kaveh; Ebrahim-Habibi, Azadeh; Moghaddasi, Azam Sadat; Tayebee, Reza; Chiti, Fabrizio*
Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations
2016 Cappelli, S; Penco, A; Mannini, Benedetta; Cascella, Roberta; Wilson, M; Ecroyd, H; Li, X; Buxbaum, J; Dobson, Cm; Cecchi, Cristina; Relini, A; Chiti, Fabrizio
Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity
2017 Mannini, Benedetta; Chiti, Fabrizio
Toxic HypF-N oligomers selectively bind the plasma membrane to impair cell adhesion capability
2018 Reinier Oropesa-Nunez, Sandeep Keshavan, Silvia Dante, Alberto Diaspro, Benedetta Mannini, Claudia Capitini, Cristina Cecchi, Massimo Stefani, Fabrizio Chiti, Claudio Canale
Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
2018 Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM
Differential interactome and innate immune response activation of two structurally distinct misfolded protein oligomers
2019 Mannini, Benedetta; Vecchi, Giulia; Labrador-Garrido, Adahir; Fabre, Bertrand; Fani, Giulia; Munoz Franco, Jaime; Lilley, Kathryn S; Pozo, David; Vendruscolo, Michele; Chiti, Fabrizio; Dobson, Christopher M; Roodveldt, Cintia
Rationally designed antibodies as research tools to study the structure–toxicity relationship of amyloid-β oligomers
2020 Limbocker R.; Mannini B.; Cataldi R.; Chhangur S.; Wright A.K.; Kreiser R.P.; Albright J.A.; Chia S.; Habchi J.; Sormanni P.; Kumita J.R.; Ruggeri F.S.; Dobson C.M.; Chiti F.; Aprile F.A.; Vendruscolo M.
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
2020 Ryan Limbocker, Benedetta Mannini, Francesco S. Ruggeri, Roberta Cascella, Catherine K. Xu, Michele Perni, Sean Chia, Serene W. Chen, Johnny Habchi, Alessandra Bigi, Ryan P. Kreiser, Aidan K. Wright, J. Alex Albright, Tadas Kartanas, Janet R. Kumita, Nunilo Cremades, Michael Zasloff, Cristina Cecchi, Tuomas P. J. Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M. Dobson
Titolo | Data di pubblicazione | Autore(i) | File |
---|---|---|---|
A causative link between the structure of aberrant protein oligomers and their toxicity | 2010 | S.Campioni;B.Mannini;M.Zampagni;A.Pensalfini;C.Parrini;E.Evangelisti;A.Relini;M.Stefani;C.M.Dobson;C.Cecchi;F.Chiti | |
Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action | 2011 | B. Mannini; S. Campioni; M. Boninsegna; E. Palagano; R. Cascella; M. Zampagni; A. Penco; M. Wilson; S. Meehan; C. Roodveldt; A. Relini; C. Cecchi; F. Chiti | |
Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils | 2011 | H.Ramshini; C.Parrini; A.Relini; M.Zampagni; B.Mannini; A.Pesce; A.A.Saboury; M.Nemat-Gorgani; F.Chiti | |
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells | 2011 | Zampagni M; Cascella R; Casamenti F; Grossi C; Evangelisti E; Wright D; Becatti M; Liguri G; Mannini B; Campioni S; Chiti F; Cecchi C. | |
The induction of α-helical structure in partially unfolded HypF-N does not affect its aggregation propensity | 2011 | B.Ahmad; I.Vigliotta; F.Tatini; S.Campioni; B.Mannini; J.Winkelmann; B.Tiribilli; F.Chiti | |
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers | 2012 | B. Mannini; R. Cascella; M. Zampagni; M. van Waarde-Verhagen; S. Meehan; C. Roodveldt; S. Campioni; M. Boninsegna; A. Penco; A. Relini; H.H. Kampinga; C.M. Dobson; M.R. Wilson; C. Cecchi; F. Chiti | |
Salt anions promote the conversion of HypF-N into amyloid-like oligomers and modulate the structure of the oligomers and the monomeric precursor state. | 2012 | Campioni S;Mannini B;López-Alonso JP;Shalova IN;Penco A;Mulvihill E;Laurents DV;Relini A;Chiti F | |
Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action | 2012 | B. Mannini; S. Campioni; M. Boninsegna; A. Penco; R. Cascella; M. Zampagni; M. Wilson; S. Meehan; C. Roodveldt; C. Dobson; A. Relini; C. Cecchi; F. Chiti | |
Glycosaminoglycans (GAGs) Suppress the Toxicity of HypF-N Prefibrillar Aggregates | 2012 | T. Saridaki; M. Zampagni; B. Mannini; E. Evangelisti; N. Taddei; C. Cecchi; F. Chiti | |
Early-forming aberrant aggregates in protein deposition diseases: structural characteristics, interaction with molecular chaperones, ability to trigger inflammation | 2013 | Benedetta Mannini | |
Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity | 2014 | Mannini B; Mulvihill E; Sgromo C; Cascella R; Khodarahmi R; Ramazzotti M; Dobson CM; Cecchi C; and Chiti F | |
SERS Detection of Amyloid Oligomers on Metallorganic-Decorated Plasmonic Beads | 2015 | Guerrini, Luca; Arenal, Raul; Mannini, Benedetta; Chiti, Fabrizio; Pini, Roberto; Matteini, Paolo; Alvarez-Puebla, Ramon A | |
Bis(indolyl)phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme | 2016 | Ramshini, Hassan; Mannini, Benedetta; Khodayari, Kaveh; Ebrahim-Habibi, Azadeh; Moghaddasi, Azam Sadat; Tayebee, Reza; Chiti, Fabrizio* | |
Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations | 2016 | Cappelli, S; Penco, A; Mannini, Benedetta; Cascella, Roberta; Wilson, M; Ecroyd, H; Li, X; Buxbaum, J; Dobson, Cm; Cecchi, Cristina; Relini, A; Chiti, Fabrizio | |
Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity | 2017 | Mannini, Benedetta; Chiti, Fabrizio | |
Toxic HypF-N oligomers selectively bind the plasma membrane to impair cell adhesion capability | 2018 | Reinier Oropesa-Nunez, Sandeep Keshavan, Silvia Dante, Alberto Diaspro, Benedetta Mannini, Claudia Capitini, Cristina Cecchi, Massimo Stefani, Fabrizio Chiti, Claudio Canale | |
Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine | 2018 | Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM | |
Differential interactome and innate immune response activation of two structurally distinct misfolded protein oligomers | 2019 | Mannini, Benedetta; Vecchi, Giulia; Labrador-Garrido, Adahir; Fabre, Bertrand; Fani, Giulia; Munoz Franco, Jaime; Lilley, Kathryn S; Pozo, David; Vendruscolo, Michele; Chiti, Fabrizio; Dobson, Christopher M; Roodveldt, Cintia | |
Rationally designed antibodies as research tools to study the structure–toxicity relationship of amyloid-β oligomers | 2020 | Limbocker R.; Mannini B.; Cataldi R.; Chhangur S.; Wright A.K.; Kreiser R.P.; Albright J.A.; Chia S.; Habchi J.; Sormanni P.; Kumita J.R.; Ruggeri F.S.; Dobson C.M.; Chiti F.; Aprile F.A.; Vendruscolo M. | |
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism | 2020 | Ryan Limbocker, Benedetta Mannini, Francesco S. Ruggeri, Roberta Cascella, Catherine K. Xu, Michele Perni, Sean Chia, Serene W. Chen, Johnny Habchi, Alessandra Bigi, Ryan P. Kreiser, Aidan K. Wright, J. Alex Albright, Tadas Kartanas, Janet R. Kumita, Nunilo Cremades, Michael Zasloff, Cristina Cecchi, Tuomas P. J. Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M. Dobson |
Legenda icone
- file ad accesso aperto
- file disponibili sulla rete interna
- file disponibili agli utenti autorizzati
- file disponibili solo agli amministratori
- file sotto embargo
- nessun file disponibile