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Titolo Data di pubblicazione Autore(i) File
A causative link between the structure of aberrant protein oligomers and their toxicity 2010 S.Campioni;B.Mannini;M.Zampagni;A.Pensalfini;C.Parrini;E.Evangelisti;A.Relini;M.Stefani;C.M.Dobson;C.Cecchi;F.Chiti
Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action 2011 B. Mannini; S. Campioni; M. Boninsegna; E. Palagano; R. Cascella; M. Zampagni; A. Penco; M. Wilson; S. Meehan; C. Roodveldt; A. Relini; C. Cecchi; F. Chiti
Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils 2011 H.Ramshini; C.Parrini; A.Relini; M.Zampagni; B.Mannini; A.Pesce; A.A.Saboury; M.Nemat-Gorgani; F.Chiti
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells 2011 Zampagni M; Cascella R; Casamenti F; Grossi C; Evangelisti E; Wright D; Becatti M; Liguri G; Mannini B; Campioni S; Chiti F; Cecchi C.
The induction of α-helical structure in partially unfolded HypF-N does not affect its aggregation propensity 2011 B.Ahmad; I.Vigliotta; F.Tatini; S.Campioni; B.Mannini; J.Winkelmann; B.Tiribilli; F.Chiti
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers 2012 B. Mannini; R. Cascella; M. Zampagni; M. van Waarde-Verhagen; S. Meehan; C. Roodveldt; S. Campioni; M. Boninsegna; A. Penco; A. Relini; H.H. Kampinga; C.M. Dobson; M.R. Wilson; C. Cecchi; F. Chiti
Salt anions promote the conversion of HypF-N into amyloid-like oligomers and modulate the structure of the oligomers and the monomeric precursor state. 2012 Campioni S;Mannini B;López-Alonso JP;Shalova IN;Penco A;Mulvihill E;Laurents DV;Relini A;Chiti F
Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action 2012 B. Mannini; S. Campioni; M. Boninsegna; A. Penco; R. Cascella; M. Zampagni; M. Wilson; S. Meehan; C. Roodveldt; C. Dobson; A. Relini; C. Cecchi; F. Chiti
Glycosaminoglycans (GAGs) Suppress the Toxicity of HypF-N Prefibrillar Aggregates 2012 T. Saridaki; M. Zampagni; B. Mannini; E. Evangelisti; N. Taddei; C. Cecchi; F. Chiti
Early-forming aberrant aggregates in protein deposition diseases: structural characteristics, interaction with molecular chaperones, ability to trigger inflammation 2013 Benedetta Mannini
Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity 2014 Mannini B; Mulvihill E; Sgromo C; Cascella R; Khodarahmi R; Ramazzotti M; Dobson CM; Cecchi C; and Chiti F
SERS Detection of Amyloid Oligomers on Metallorganic-Decorated Plasmonic Beads 2015 Guerrini, Luca; Arenal, Raul; Mannini, Benedetta; Chiti, Fabrizio; Pini, Roberto; Matteini, Paolo; Alvarez-Puebla, Ramon A
Bis(indolyl)phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme 2016 Ramshini, Hassan; Mannini, Benedetta; Khodayari, Kaveh; Ebrahim-Habibi, Azadeh; Moghaddasi, Azam Sadat; Tayebee, Reza; Chiti, Fabrizio*
Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations 2016 Cappelli, S; Penco, A; Mannini, Benedetta; Cascella, Roberta; Wilson, M; Ecroyd, H; Li, X; Buxbaum, J; Dobson, Cm; Cecchi, Cristina; Relini, A; Chiti, Fabrizio
Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity 2017 Mannini, Benedetta; Chiti, Fabrizio
Toxic HypF-N oligomers selectively bind the plasma membrane to impair cell adhesion capability 2018 Reinier Oropesa-Nunez, Sandeep Keshavan, Silvia Dante, Alberto Diaspro, Benedetta Mannini, Claudia Capitini, Cristina Cecchi, Massimo Stefani, Fabrizio Chiti, Claudio Canale
Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine 2018 Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM
Differential interactome and innate immune response activation of two structurally distinct misfolded protein oligomers 2019 Mannini, Benedetta; Vecchi, Giulia; Labrador-Garrido, Adahir; Fabre, Bertrand; Fani, Giulia; Munoz Franco, Jaime; Lilley, Kathryn S; Pozo, David; Vendruscolo, Michele; Chiti, Fabrizio; Dobson, Christopher M; Roodveldt, Cintia
Rationally designed antibodies as research tools to study the structure–toxicity relationship of amyloid-β oligomers 2020 Limbocker R.; Mannini B.; Cataldi R.; Chhangur S.; Wright A.K.; Kreiser R.P.; Albright J.A.; Chia S.; Habchi J.; Sormanni P.; Kumita J.R.; Ruggeri F.S.; Dobson C.M.; Chiti F.; Aprile F.A.; Vendruscolo M.
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism 2020 Ryan Limbocker, Benedetta Mannini, Francesco S. Ruggeri, Roberta Cascella, Catherine K. Xu, Michele Perni, Sean Chia, Serene W. Chen, Johnny Habchi, Alessandra Bigi, Ryan P. Kreiser, Aidan K. Wright, J. Alex Albright, Tadas Kartanas, Janet R. Kumita, Nunilo Cremades, Michael Zasloff, Cristina Cecchi, Tuomas P. J. Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M. Dobson
Mostrati risultati da 1 a 20 di 24
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