Sfoglia per Autore
Melatonin treatment delays reproductive aging of female rat via the opiatergic system
1992 Trentini GP, Genazzani AR, Criscuolo M, Petraglia F, De Gaetani C, Ficarra G, Bidzinska B, Migaldi M, Genazzani AD.
Pituitary and ovarian interleukin-1 alpha content changes according to estrous cycle and acute stress exposure
1994 Nappi, R.E.*; Guo, A.-L.; Petraglia, F.; Bonati, M.E.; Criscuolo, M.; Ficarra, G.; Zara, C.; Genazzani, A.R.
Acute stress- or lipopolysaccharide-induced corticosterone secretion in female rats is independent of the oestrous cycle
1994 Guo, A.-L.*; Petraglia, F.; Criscuolo, M.; Ficarra, G.; Nappi, R.E.; Palumbo, M.; Valentini, A.; Genazzani, A.R.
Ontogeny of the circadian rhythm in medial basal hypothalamic Ã-endorphin content in female rat
1994 Criscuolo, M.*; De Gaetani, C.; Ficarra, G.; Nappi, R.E.; Migaldi, M.; Petraglia, F.; Genazzani, A.R.; Trentini, G.P.
The present study investigated the effect of allopregnanolone (5α-pregnan-3α-ol-20-one) or of passive immunoneutralization of brain allopregnanolone, the most potent steroid produced by neurons, on ovulation rate and sexual behavior in female rats. Allopregnanolone was injected intracerebroventricularly in rats on diestrus and proestrus and tests were done on estrus. The intracerebroventricular injection of allopregnanolone significantly decreased the number of oocytes collected on estrus (p < 0.01). To support a physiological involvement, antiserum to allopregnanolone was injected centrally to block the activity of the endogenous neurosteroid. When administered on diestrus and proestrus or only on proestrus, the antiserum was shown to be correlated with a significant increase (p < 0.01) in oocytes retrieved on estrus. In female rats treated with antiserum to allopregnanolone, the lordosis intensity was augmented significantly as compared to controls. Finally, the possible changes of medial basal hypothalamus concentration of allopregnanolone throughout the estrous cycle and at the time of ovulation were investigated. Hypothalamic extracts were eluted on highpressure liquid chromatography and allopregnanolone concentration was measured by radioimmunoassay. Brain cortex was used as control tissue. Hypothalamic allopregnanolone concentration on proestrus morning and afternoon was found to be significantly lower than in the remaining phases of the estrous cycle (p < 0.01), while no significant changes were observed in brain cortex concentration of allopregnanolone. The present results suggest that hypothalamic allopregnanolone may be involved in the mechanism of ovulation, affecting hormonal and behavioral events.
1995 Genazzani AR, Palumbo MA, de Micheroux AA, Artini PG, Criscuolo M, Ficarra G, Guo AL, Benelli A, Bertolini A, Petraglia F, Purdy RH.
Evidence for a role of neurosteroids in modulation of diurnal changes and acute stress-induced corticosterone secretion in rats
1995 Guo, A.L.*; Petraglia, F.; Criscuolo, M.; Ficarra, G.; Nappi, R.E.; Palumbo, M.A.; Trentini, G.P.; Purdy, R.H.; Genazzani, A.R.
Adrenergic and serotoninergic receptors mediate the immunological activation of corticosterone secretion in male rats
1996 Guo, A.-L.*; Petraglia, F.; Criscuolo, M.; Ficarra, G.; Salvestroni, C.; Nappi, R.E.; Trentini, G.P.; Genazzani, A.R.
Bicuculline enhances the corticosterone secretion induced by lipopolysaccharide and interleukin-1alpha in male rats
1996 Quo, A.L.*; Petraglia, F.; Nappi, R.E.; Criscuolo, M.; Ficarra, G.; Salvestroni, C.; Genazzani, A.D.; Trentini, G.P.; Genazzani, A.R.
Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus
2014 Piccinni M.P.; Lombardelli L.; Logiodice F.; Tesi D.; Kullolli O.; Biagiotti R.; Giudizi M.G.; Romagnani S.; Maggi E.; Ficarra, G.
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