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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. 2007 Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P.
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. 2008 Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R.
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. 2010 Nassini R, Materazzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Patacchini R, Geppetti P.
Oxaliplatin elicits mechanical and cold allodynia via TRPA1 receptor stimulation and oxidative stress byproducts 2011 Nassini R, Marteen G, Harrison S, De Siena G, Materazzi S, Moretto N, Failli P, Preti D, Marchetti N, Cavazzini A, Mancini F, Pedretti P, Nilius B, Patacchini R, Geppetti P.
OXALIPLATIN ELICITS MECHANICAL AND COLD ALLODYNIA IN RODENTS VIA TRPA1 RECEPTOR STIMULATION 2011 Nassini R, Gees M, Harrison S, De Siena G, Materazzi S, Moretto N, Failli P, Preti D, Marchetti N, Cavazzini A, Mancini F, Pedretti P, Nilius B, Patacchini R, Geppetti P.
TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism 2012 Materazzi S, Fusi C, Benemei S, Pedretti P, Patacchini R, Nilius B, Prenen J, Creminon C, Geppetti P, Nassini R.
Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation 2012 Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, Facchinetti F, Viscomi AR, Pisano AR, Stokesberry S, Brunmark C, Svitacheva N, McGarvey L, Patacchini R, Damholt AB, Geppetti P, Materazzi S.
Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade 2013 Trevisan G, Materazzi S, Fusi C, Altomare A, Aldini G, Lodovici M, Patacchini R, Geppetti P, Nassini R.
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel 2013 Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R.
Transient receptor potential channels and occupational exposure. 2014 Geppetti P, Patacchini R, Nassini R.
Functional characterization of human ProNGF and NGF mutants: Identification of NGF P61SR100E as a "Painless" lead investigational candidate for therapeutic applications 2015 Malerba F, Paoletti F, Ercole BB, Materazzi S, Nassini R, Coppi E, Patacchini R, Capsoni S, Lamba D, Cattaneo A.
The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives 2015 Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R, Chiarugi A, Patacchini R, Geppetti P, Benemei S.
TRP functions in the broncho-pulmonary system 2016 De Logu, Francesco; Patacchini, Riccardo; Fontana, Giovanni; Geppetti, Pierangelo
Vasodilator activity of hydrogen sulfide (H2S) in human mesenteric arteries 2016 Materazzi S, Zagli G, Nassini R, Bartolini I, Romagnoli S, Chelazzi C, Benemei S, Coratti A, De Gaudio AR, Patacchini R.
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice 2017 De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl'Innocenti D, Marone IM, Ferreira J, Li Puma S, Benemei S, Trevisan G, Souza Monteiro De Araújo D, Patacchini R, Bunnett NW, Geppetti, P.
TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal 2019 Li Puma S.; Landini L.; Macedo S.J.; Seravalli V.; Marone I.M.; Coppi E.; Patacchini R.; Geppetti P.; Materazzi S.; Nassini R.; De Logu F.
Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice 2019 De Logu, Francesco; Li Puma, Simone; Landini, Lorenzo; Portelli, Francesca; Innocenti, Alessandro; de Araújo, Daniel Souza Monteiro; Janal, Malvin N; Patacchini, Riccardo; Bunnett, Nigel W; Geppetti, Pierangelo; Nassini, Romina
The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel 2019 De Logu F.; Li Puma S.; Landini L.; Tuccinardi T.; Poli G.; Preti D.; De Siena G.; Patacchini R.; Tsagareli M.G.; Geppetti P.; Nassini R.
Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief 2022 Iannone L.F.; Nassini R.; Patacchini R.; Geppetti P.; De Logu F.
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