Distribuzione geografica
Continente #
NA - Nord America 37.310
EU - Europa 9.944
AS - Asia 1.801
AF - Africa 19
Continente sconosciuto - Info sul continente non disponibili 16
SA - Sud America 9
OC - Oceania 8
Totale 49.107
Nazione #
US - Stati Uniti d'America 37.232
SE - Svezia 2.230
PL - Polonia 2.226
IE - Irlanda 1.964
IT - Italia 1.184
HK - Hong Kong 886
FI - Finlandia 609
DE - Germania 604
UA - Ucraina 454
GB - Regno Unito 429
TR - Turchia 370
IN - India 148
CN - Cina 135
JO - Giordania 113
VN - Vietnam 80
CA - Canada 78
CH - Svizzera 48
BE - Belgio 41
KR - Corea 41
FR - Francia 36
NL - Olanda 35
ES - Italia 28
RU - Federazione Russa 26
EU - Europa 16
SG - Singapore 16
SC - Seychelles 14
AT - Austria 9
RO - Romania 7
BG - Bulgaria 6
BR - Brasile 6
NZ - Nuova Zelanda 5
IR - Iran 4
JP - Giappone 4
AU - Australia 3
DK - Danimarca 3
AR - Argentina 2
LT - Lituania 2
MU - Mauritius 2
AZ - Azerbaigian 1
BY - Bielorussia 1
CO - Colombia 1
CZ - Repubblica Ceca 1
EG - Egitto 1
GR - Grecia 1
ID - Indonesia 1
NG - Nigeria 1
SA - Arabia Saudita 1
TW - Taiwan 1
ZA - Sudafrica 1
Totale 49.107
Città #
Fairfield 7.911
Woodbridge 3.616
Seattle 3.265
Ashburn 3.185
Cambridge 3.075
Houston 2.826
Wilmington 2.509
Warsaw 2.224
Chandler 2.076
Dublin 1.962
Jacksonville 1.161
Ann Arbor 1.067
Lawrence 863
Altamura 733
Princeton 639
Boardman 482
Medford 396
Boston 333
San Diego 301
Izmir 300
Hong Kong 186
Florence 141
Norwalk 126
Beijing 81
Falls Church 77
Andover 70
Buffalo 70
Hillsboro 65
Dong Ket 64
Dearborn 62
Toronto 59
Bern 48
Düsseldorf 44
Milan 43
New York 42
Brussels 41
London 41
Kent 36
Shanghai 31
Los Angeles 28
Auburn Hills 26
Barcelona 25
Tappahannock 23
Laurel 22
Phoenix 18
Redmond 16
Salerno 16
Frankfurt Am Main 15
Chiswick 14
West Jordan 14
Kilburn 12
Bremen 11
Grevenbroich 11
Redwood City 11
San Mateo 11
Prescot 10
Verona 10
Hounslow 9
Singapore 9
Vienna 9
Gavirate 8
Moscow 8
Old Bridge 8
Seoul 8
Detroit 7
Rome 7
Seongnam 7
Leawood 6
Montréal 6
Napoli 6
New Bedfont 6
Scandicci 6
Siena 6
Timisoara 6
Trumbull 6
Arnsberg 5
Chicago 5
Helsinki 5
Incisa 5
Naaldwijk 5
Sofia 5
Southwark 5
Washington 5
Yaroslavl 5
Abbotsford 4
Bari 4
Jinan 4
Saint-Fons 4
Serra 4
Venice 4
Winnipeg 4
Araraquara 3
Copenhagen 3
Fuzhou 3
Groningen 3
Islington 3
Lappeenranta 3
Naples 3
Nuremberg 3
Palermo 3
Totale 40.772
Nome #
A 31P NMR study of phosphate in presence of cobalt(II)- and copper(II)- substituted bovine carbonic anhydrase B. 277
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. 254
Biotransformation of Chloroaromatics: the Impact of Bioavailability and Substrate Specificity. 250
Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors. 242
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates. 239
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. 238
Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II. 223
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis 216
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis 212
Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. 212
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. 209
Assembly comprising an absorber of near infrared (nir) light covalently linked to an inhibitor of carbonic anhydrase 208
Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms. 203
Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases. 195
Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. 186
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives? 166
Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase 146
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors 141
Biodegradation of 2-naphthalensulfonic acid polymers by white-rot fungi: Scale-up into non-sterile packed bed bioreactors 141
Next-generation polyamine human carbonic anhydrase inhibitors 140
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition 140
Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase. 130
Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor. 128
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense. 123
3D QSAR selectivity analyses of carbonic anhydrase inhibitors: insights for the design of isozyme selective inhibitors. 122
1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads 120
Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA. 118
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. 118
Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances. 117
Antiglaucoma carbonic anhydrase inhibitors: a patent review. 117
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. 116
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. 115
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. 115
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. 115
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors. 114
Antiobesity carbonic anhydrase inhibitors: a literature and patent review. 113
Characterization of the biological conversion of naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene in direct micellar systems 112
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. 112
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. 112
Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents 112
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. 111
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides. 110
Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II. 110
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. 110
Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions. 110
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis 110
Combined action of a bacterial monooxygenase and a fungal laccase for the biodegradation of mono- and poly-aromatic hydrocarbons. 109
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions. 109
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails. 108
Polyamines and α-carbonic anhydrases 108
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. 108
N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. 108
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines. 108
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines. 108
Carbonic anhydrase IX: a new druggable target for the design of antitumor agents. 107
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates. 107
Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations. 107
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates. 107
A class of 4-Sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects. 107
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors. 107
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols. 107
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII. 107
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators. 107
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors. 107
Efficient polycyclic aromatic hydrocarbons dihydroxylation in direct micellar systems 106
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides. 106
Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus. 106
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue. 105
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines. 105
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies. 105
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX. 105
Unsymmetrical 1,1'-disubstituted ferrocenes: synthesis of Co(ii), Cu(ii), Ni(ii) and Zn(ii) chelates of ferrocenyl -1-thiadiazolo-1'-tetrazole, -1-thiadiazolo-1'-triazole and -1-tetrazolo-1'-triazole with antimicrobial properties. 105
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors. 105
Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups. 105
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. 104
Carbonic anhydrase inhibitors. Part 54: metal complexes of heterocyclic sulfonamides: a new class of antiglaucoma agents. 104
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II. 104
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. 104
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. 104
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV. 104
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines. 104
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. 104
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors? 104
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII. 103
Carbonic Anhydrase Inhibitors. Part 55 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV. 103
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. 103
QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software. 103
Complexes with biologically active ligands. Part 11. Synthesis and carbonic anhydrase inhibitory activity of metal complexes of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives. 103
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. 103
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors. 103
5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors. 103
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. 103
Metalloantibiotics: synthesis and antibacterial activity of cobalt(II), copper(II), nickel(II) and zinc(II) complexes of kefzol. 103
Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII. 103
Metalloenzyme inhibitors for the treatment of Gram-negative bacterial infections: a patent review (2009 - 2012). 103
Plasmonic Particles that Hit Hypoxic Cells 103
Crystallization and preliminary structure analysis of the blue laccase from the ligninolytic fungus Panus tigrinus. 103
Carbonic Anhydrase Interaction With Lipothioars Enites: A Novel Class of Isozymes I and II Inhibitors. 103
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides. 103
X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: New perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity. 103
Totale 12.804
Categoria #
all - tutte 124.756
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 124.756

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20196.609 0 0 0 0 0 0 0 0 0 0 3.533 3.076
2019/202015.025 1.472 901 403 1.320 1.763 1.947 1.822 1.942 1.701 725 711 318
2020/20216.853 732 566 619 395 231 864 203 597 682 782 554 628
2021/20224.241 247 446 502 116 169 182 234 256 164 178 623 1.124
2022/20239.115 1.103 1.841 135 674 846 1.739 865 642 801 39 276 154
2023/20242.180 157 401 623 157 141 272 46 264 27 39 53 0
Totale 49.244