Cerebral small-vessel alterations play a central role in determining lesions of subcortical structures and eventually may lead to cognitive impairment. Small-vessel diseases are classified according to the pathological viewpoint. The most important ones are the changes in small arteries and arterioles caused by prolonged hypertension. These small-vessel changes may result in ischemic damage to the brain parenchyma and blood-barrier alterations. Both mechanisms are thought to contribute to the occurrence of white-matter changes and lacunar infarcts. Modern magnetic resonance techniques such as diffusion, perfusion, and spectroscopy may allow the in vivo study of the pathophysiology of small-vessel diseases and the consequences on the brain parenchyma.
Pathophysiology of cerebral small vessels in vascular cognitive impairment / Pantoni, Leonardo; Simoni, Michela. - In: INTERNATIONAL PSYCHOGERIATRICS. - ISSN 1041-6102. - ELETTRONICO. - 15 Suppl 1:(2003), pp. 59-65. [10.1017/S1041610203008974]
Pathophysiology of cerebral small vessels in vascular cognitive impairment
PANTONI, LEONARDO;
2003
Abstract
Cerebral small-vessel alterations play a central role in determining lesions of subcortical structures and eventually may lead to cognitive impairment. Small-vessel diseases are classified according to the pathological viewpoint. The most important ones are the changes in small arteries and arterioles caused by prolonged hypertension. These small-vessel changes may result in ischemic damage to the brain parenchyma and blood-barrier alterations. Both mechanisms are thought to contribute to the occurrence of white-matter changes and lacunar infarcts. Modern magnetic resonance techniques such as diffusion, perfusion, and spectroscopy may allow the in vivo study of the pathophysiology of small-vessel diseases and the consequences on the brain parenchyma.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.