OBJECTIVE: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). METHODS: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD. RESULTS: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD. CONCLUSION: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation

Skin CD30+ T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease / Amedei, Amedeo; Pimpinelli, Nicola; Grassi, Alessia; Bella, Chiara Della; Niccolai, Elena; Brancati, Simona; Benagiano, Marisa; D'Elios, Sofia; Bosi, Alberto; D'Elios, Mario M. - In: AUTOIMMUNITY HIGHLIGHTS. - ISSN 2038-0305. - ELETTRONICO. - 5:(2014), pp. 21-26. [10.1007/s13317-013-0054-7]

Skin CD30+ T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease

AMEDEI, AMEDEO;PIMPINELLI, NICOLA;GRASSI, ALESSIA;NICCOLAI, ELENA;BRANCATI, SIMONA;BENAGIANO, MARISA;BOSI, ALBERTO;D'ELIOS, MARIO MILCO
2014

Abstract

OBJECTIVE: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). METHODS: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD. RESULTS: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD. CONCLUSION: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation
2014
5
21
26
Amedei, Amedeo; Pimpinelli, Nicola; Grassi, Alessia; Bella, Chiara Della; Niccolai, Elena; Brancati, Simona; Benagiano, Marisa; D'Elios, Sofia; Bosi, Alberto; D'Elios, Mario M
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1046128
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