Associations between sex steroids and the development of metabolic syndrome: A longitudinal study in European men

Antonio, Leen; Frederick C. W., Wu; O'Neill, Terence W.; Pye, Stephen R.; Carter, Emma L.; Finn, Joseph D.; Rutter, Martin K.; Laurent, Michaël R.; Huhtaniemi, Ilpo T.; Han, Thang S.; Lean, Michael E. J.; Keevil, Brian G.; Pendleton, Neil; Rastrelli, Giulia; Forti, Gianni; Bartfai, Gyorgy; Casanueva, Felipe F.; Kula, Krzysztof; Punab, Margus; Giwercman, Aleksander; Claessens, Frank; Decallonne, Brigitte; Vanderschueren, Dirk

doi:10.1210/jc.2014-4184

Low testosterone (T) has been associated with incident metabolic syndrome (MetS), but it remains unclear if this association is independent of sex hormone binding globulin (SHBG). Estradiol (E2) may also be associated with MetS, but few studies have investigated this. The aim of the study is to assess the association between baseline sex steroids and the development of incident MetS and to investigate the influence of SHBG, body mass index (BMI) and insulin resistance on this risk.

Associations between sex steroids and the development of metabolic syndrome: A longitudinal study in European men / Antonio, Leen; Wu, Frederick C. W.; O'Neill, Terence W.; Pye, Stephen R.; Carter, Emma L.; Finn, Joseph D.; Rutter, Martin K.; Laurent, Michaël R.; Huhtaniemi, Ilpo T.; Han, Thang S.; Lean, Michael E. J.; Keevil, Brian G.; Pendleton, Neil; Rastrelli, Giulia; Forti, Gianni; Bartfai, Gyorgy; Casanueva, Felipe F.; Kula, Krzysztof; Punab, Margus; Giwercman, Aleksander; Claessens, Frank; Decallonne, Brigitte; Vanderschueren, Dirk.. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - STAMPA. - 100:(2015), pp. 1396-1404. [10.1210/jc.2014-4184]