The t(15;17) chromosomal translocation in acute promyelocytic leukemia (APL) results in the expression of the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARa) fusion protein. This single gene rearrangement makes APL a unique malignancy because its oncogenic effect can be overcome by retinoic acid treatment. PML/RARa-induced leukemogenesis is a multistep process that extends beyond disruption of PML and RARa functions and requires cooperating events.
Role of PML/RARα in the pathogenesis of APL / Anna, Laurenzana; Filippa, Pettersson; Wilson, Miller. - In: DRUG DISCOVERY TODAY: DISEASE MECHANISMS. - ISSN 1740-6765. - ELETTRONICO. - 3:(2006), pp. 500-505.
Role of PML/RARα in the pathogenesis of APL
Anna, Laurenzana;
2006
Abstract
The t(15;17) chromosomal translocation in acute promyelocytic leukemia (APL) results in the expression of the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARa) fusion protein. This single gene rearrangement makes APL a unique malignancy because its oncogenic effect can be overcome by retinoic acid treatment. PML/RARa-induced leukemogenesis is a multistep process that extends beyond disruption of PML and RARa functions and requires cooperating events.
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