The development of functional assays with u-RPC obtained from patients with genetic kidney disorders could serve as a fundamental step for rapid testing of putative pathogenic mutations. In particular, this tool can provide an essential support for the clinical diagnosis of nephrotic syndrome in patients carrying variants of uncertain significance in podocyte genes. The results of this study demonstrate that u-RPC cultures represent an innovative research tool which provide information to optimize an affected individual’s personalized medical care.

URINE-DERIVED HUMAN RENAL PROGENITOR CULTURES FOR MODELING OF GENETIC KIDNEY DISORDERS / Lazzeri, E; Ronconi, E; Angelotti, Ml; Peired, Aj; Mazzinghi, B; Becherucci, F; Sansavini, G; Sisti, A; Provenzano, A; Giglio, S; Lasagni, L; Romagnani, P. - In: NEPHROLOGY DIALYSIS TRANSPLANTATION. - ISSN 0931-0509. - STAMPA. - 29:(2014), pp. 570-570.

URINE-DERIVED HUMAN RENAL PROGENITOR CULTURES FOR MODELING OF GENETIC KIDNEY DISORDERS

LAZZERI, ELENA;RONCONI, ELISA;ANGELOTTI, MARIA LUCIA;PEIRED, ANNA JULIE;PROVENZANO, ALDESIA;GIGLIO, SABRINA RITA;LASAGNI, LAURA;ROMAGNANI, PAOLA
2014

Abstract

The development of functional assays with u-RPC obtained from patients with genetic kidney disorders could serve as a fundamental step for rapid testing of putative pathogenic mutations. In particular, this tool can provide an essential support for the clinical diagnosis of nephrotic syndrome in patients carrying variants of uncertain significance in podocyte genes. The results of this study demonstrate that u-RPC cultures represent an innovative research tool which provide information to optimize an affected individual’s personalized medical care.
2014
Lazzeri, E; Ronconi, E; Angelotti, Ml; Peired, Aj; Mazzinghi, B; Becherucci, F; Sansavini, G; Sisti, A; Provenzano, A; Giglio, S; Lasagni, L; Romagnani, P
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1062164
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