Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients

Psoriasis vulgaris is an inflammatory systemic disease with unclear pathogenesis characterized by the appearance of scaly erythematous plaques on the skin. These plaques are the sites of keratinocytes hyper-proliferation and misdifferentiation and inflammatory infiltration by T cells skewed toward Th1/Th17 with respect to Th2/TREG. Such disequilibrium between T cells population features psoriasis as an autoimmune disease [1]. A prominent attention is given to biologic drugs aimed to restore the balance between T cells populations in psoriasis: the use of antibodies against the overproduced cytokines or the use of cytokines-antagonists represent two successful strategies that have been shown to ameliorate Psoriasis Area Severity Index (PASI). Although targeting specific parts of immune system, such treatments require the use of high dose biologics and are frequently associated with adverse effects