Carboxylates are the least investigated class of inhibitors of carbonic anhydrases (CAs). Here we explain the versatility of binding of these molecules to CAs by examining a new adduct of hCA II with N-carboxymethyl-saccharin
A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases / Langella, Emma; D'Ambrosio, Katia; D'Ascenzio, Melissa; Carradori, Simone; Monti, Simona M.; Supuran, Claudiu T.; De Simone, Giuseppina. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - ELETTRONICO. - 22:(2016), pp. 97-100. [10.1002/chem.201503748]
A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases
SUPURAN, CLAUDIU TRANDAFIR;
2016
Abstract
Carboxylates are the least investigated class of inhibitors of carbonic anhydrases (CAs). Here we explain the versatility of binding of these molecules to CAs by examining a new adduct of hCA II with N-carboxymethyl-saccharinI documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.