Celiac disease (CD) is an immune-mediated disorder characterized by an accumulation of immune cells in the duodenal mucosa as a consequence of both adaptive and innate immune responses to undigested gliadin peptides. Mast cells (MCs) are innate immune cells that are a major source of costimulatory signals and inflammatory mediators in the intestinal mucosa. Although MCs have previously been associated with CD, functional studies have never been performed.
Mast cells are associated with the onset and progression of celiac disease / Frossi, Barbara; Tripodo, Claudio; Guarnotta, Carla; Carroccio, Antonio; De Carli, Marco; De Carli, Stefano; Marino, Marco; Calabro', ANTONINO SALVATORE; Pucillo, Carlo E.. - In: THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. - ISSN 1097-6825. - STAMPA. - 139:(2017), pp. 1266-1274. [10.1016/j.jaci.2016.08.011]
Mast cells are associated with the onset and progression of celiac disease
CALABRO', ANTONINO SALVATORE;
2017
Abstract
Celiac disease (CD) is an immune-mediated disorder characterized by an accumulation of immune cells in the duodenal mucosa as a consequence of both adaptive and innate immune responses to undigested gliadin peptides. Mast cells (MCs) are innate immune cells that are a major source of costimulatory signals and inflammatory mediators in the intestinal mucosa. Although MCs have previously been associated with CD, functional studies have never been performed.
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