Approximately 10 years ago, after publication of very poorlyinvestigated case reports, a discussion began on a “hepatotoxic risk”associated with the ingestion of Cimicifuga preparations. After sev-eral years and thorough evaluations by numerous research groupsand responsible authorities (e.g. the HMPC) this risk was not sub-stantiated.A similar discussion has now been started following a publica-tion in March 2013 of a report by the National Toxicology Program(NTP) of the U.S. Department of Health and Human Services on“Toxicology and Carcinogenesis: Studies of Ginkgo biloba Extractin Rats and Mice” (NIH Publication No. 13-5920). According to theauthors the reason for the experiments was the widespread use ofGinkgo products and the content of quercetin in such preparations.From the results of the 2-year carcinogenicity studies it is concludedthat the investigated Ginkgo biloba extract caused cancers of thethyroid gland in male and female rats and male mice and cancers ofthe liver in male and female mice. The discrepancies between theresults presented in this report and the proof of safety, togetherwith long-standing experiences in Europe with herbal medicinalproducts (HMPs) containing a specific Ginkgo extract (EGb 761)

Now Ginkgo – 10 years after Cimicifuga? / Liselotte Krenn; Anna Rita Bilia; Maria do Céu Costa; Ingrid Hook; Barbara Steinhoff; Tankred Wegener. - In: PHYTOMEDICINE. - ISSN 0944-7113. - ELETTRONICO. - (2014), pp. 98-99.

Now Ginkgo – 10 years after Cimicifuga?

Anna Rita Bilia;
2014

Abstract

Approximately 10 years ago, after publication of very poorlyinvestigated case reports, a discussion began on a “hepatotoxic risk”associated with the ingestion of Cimicifuga preparations. After sev-eral years and thorough evaluations by numerous research groupsand responsible authorities (e.g. the HMPC) this risk was not sub-stantiated.A similar discussion has now been started following a publica-tion in March 2013 of a report by the National Toxicology Program(NTP) of the U.S. Department of Health and Human Services on“Toxicology and Carcinogenesis: Studies of Ginkgo biloba Extractin Rats and Mice” (NIH Publication No. 13-5920). According to theauthors the reason for the experiments was the widespread use ofGinkgo products and the content of quercetin in such preparations.From the results of the 2-year carcinogenicity studies it is concludedthat the investigated Ginkgo biloba extract caused cancers of thethyroid gland in male and female rats and male mice and cancers ofthe liver in male and female mice. The discrepancies between theresults presented in this report and the proof of safety, togetherwith long-standing experiences in Europe with herbal medicinalproducts (HMPs) containing a specific Ginkgo extract (EGb 761)
2014
98
99
Liselotte Krenn; Anna Rita Bilia; Maria do Céu Costa; Ingrid Hook; Barbara Steinhoff; Tankred Wegener
File in questo prodotto:
File Dimensione Formato  
ginkgo and bilia 2013.pdf

Accesso chiuso

Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 180.81 kB
Formato Adobe PDF
180.81 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1090274
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 2
social impact