Approximately 10 years ago, after publication of very poorlyinvestigated case reports, a discussion began on a “hepatotoxic risk”associated with the ingestion of Cimicifuga preparations. After sev-eral years and thorough evaluations by numerous research groupsand responsible authorities (e.g. the HMPC) this risk was not sub-stantiated.A similar discussion has now been started following a publica-tion in March 2013 of a report by the National Toxicology Program(NTP) of the U.S. Department of Health and Human Services on“Toxicology and Carcinogenesis: Studies of Ginkgo biloba Extractin Rats and Mice” (NIH Publication No. 13-5920). According to theauthors the reason for the experiments was the widespread use ofGinkgo products and the content of quercetin in such preparations.From the results of the 2-year carcinogenicity studies it is concludedthat the investigated Ginkgo biloba extract caused cancers of thethyroid gland in male and female rats and male mice and cancers ofthe liver in male and female mice. The discrepancies between theresults presented in this report and the proof of safety, togetherwith long-standing experiences in Europe with herbal medicinalproducts (HMPs) containing a specific Ginkgo extract (EGb 761)
Now Ginkgo – 10 years after Cimicifuga? / Liselotte Krenn; Anna Rita Bilia; Maria do Céu Costa; Ingrid Hook; Barbara Steinhoff; Tankred Wegener. - In: PHYTOMEDICINE. - ISSN 0944-7113. - ELETTRONICO. - (2014), pp. 98-99.
Now Ginkgo – 10 years after Cimicifuga?
Anna Rita Bilia;
2014
Abstract
Approximately 10 years ago, after publication of very poorlyinvestigated case reports, a discussion began on a “hepatotoxic risk”associated with the ingestion of Cimicifuga preparations. After sev-eral years and thorough evaluations by numerous research groupsand responsible authorities (e.g. the HMPC) this risk was not sub-stantiated.A similar discussion has now been started following a publica-tion in March 2013 of a report by the National Toxicology Program(NTP) of the U.S. Department of Health and Human Services on“Toxicology and Carcinogenesis: Studies of Ginkgo biloba Extractin Rats and Mice” (NIH Publication No. 13-5920). According to theauthors the reason for the experiments was the widespread use ofGinkgo products and the content of quercetin in such preparations.From the results of the 2-year carcinogenicity studies it is concludedthat the investigated Ginkgo biloba extract caused cancers of thethyroid gland in male and female rats and male mice and cancers ofthe liver in male and female mice. The discrepancies between theresults presented in this report and the proof of safety, togetherwith long-standing experiences in Europe with herbal medicinalproducts (HMPs) containing a specific Ginkgo extract (EGb 761)File | Dimensione | Formato | |
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