Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO₂ and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO₂ capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action.

An Overview of the Bacterial Carbonic Anhydrases / Supuran, Claudiu T; Capasso, Clemente. - In: METABOLITES. - ISSN 2218-1989. - ELETTRONICO. - 7:(2017), pp. 1-19. [10.3390/metabo7040056]

An Overview of the Bacterial Carbonic Anhydrases

Supuran, Claudiu T
;
2017

Abstract

Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO₂ and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO₂ capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action.
2017
7
1
19
Supuran, Claudiu T; Capasso, Clemente
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1105092
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