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EnglishAn inverse procedure is developed and tested to recover functional and structural information from global signals of brains activity. The method assumes a leaky-integrate and fire model with excitatory and inhibitory neurons, coupled via a directed network. Neurons are endowed with a heterogenous current value, which sets their associated dynamical regime. By making use of a heterogenous mean-field approximation, the method seeks to reconstructing from global activity patterns the distribution of in-coming degrees, for both excitatory and inhibitory neurons, as well as the distribution of the assigned currents. The proposed inverse scheme is first validated against synthetic data. Then, time-lapse acquisitions of a zebrafish larva recorded with a two-photon light sheet microscope are used as an input to the reconstruction algorithm. A power law distribution of the in-coming connectivity of the excitatory neurons is found. Local degree distributions are also computed by segmenting the whole brain in sub-regions traced from annotated atlas.
| Titolo: | Reconstruction scheme for excitatory and inhibitory dynamics with quenched disorder: application to zebrafish imaging |
| Autori di Ateneo: | |
| Autori: | Chicchi, Lorenzo; Cecchini, Gloria; Adam, Ihusan; de Vito, Giuseppe; Livi, Roberto; Pavone, Francesco Saverio; Silvestri, Ludovico; Turrini, Lapo; Vanzi, Francesco; Fanelli, Duccio |
| Presenza coautori internazionali: | No |
| Numero degli autori: | 10 |
| Anno di registrazione: | 2021 |
| Rivista: | |
| Pagina iniziale: | 0 |
| Pagina finale: | 0 |
| Numero di pagine: | 1 |
| Pubblicazione con Impact Factor: | Sì |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10827-020-00774-1 |
| URL: | https://link.springer.com/article/10.1007/s10827-020-00774-1 |
| Area scientifico-disciplinare: | SCIENZE BIOLOGICHE SCIENZE FISICHE SCIENZE STORICHE, FILOSOFICHE, PSICOLOGICHE E PEDAGOGICHE |
| Parole Chiave: | disorder, zebrafish, light-sheet, two-photon |
| Abstract: | An inverse procedure is developed and tested to recover functional and structural information from global signals of brains activity. The method assumes a leaky-integrate and fire model with excitatory and inhibitory neurons, coupled via a directed network. Neurons are endowed with a heterogenous current value, which sets their associated dynamical regime. By making use of a heterogenous mean-field approximation, the method seeks to reconstructing from global activity patterns the distribution of in-coming degrees, for both excitatory and inhibitory neurons, as well as the distribution of the assigned currents. The proposed inverse scheme is first validated against synthetic data. Then, time-lapse acquisitions of a zebrafish larva recorded with a two-photon light sheet microscope are used as an input to the reconstruction algorithm. A power law distribution of the in-coming connectivity of the excitatory neurons is found. Local degree distributions are also computed by segmenting the whole brain in sub-regions traced from annotated atlas. |
| Formato: | ELETTRONICO |
| Tipo di prodotto: | Contributo di ricerca |
| Lingua: | Inglese |
| Rilevanza: | Internazionale |
| Revisione (peer review): | Esperti anonimi |
| Handle: | http://hdl.handle.net/2158/1233945 |
| Appare nelle tipologie: | 1a - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Chicchi2021_Article_ReconstructionSchemeForExcitat.pdf | Articolo principale, in stampa | PDF editoriale |  | Accesso pubblicoVisualizza/Apri |
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