Experimental evidence is growing that in patients with brain subcortical vascular changes a major role is played by angiotensin (Ang)II-mediated inflammation, also supported by reported positive effects of Ang II antagonists. Human cerebral renin angiotensin system (RAS) cannot be directly investigated and Ang II does not cross cerebral barrier. A cell-based RAS was shown in T-lymphocyte able to sustain an autonomous Ang II synthesis independently of circulating and tissue RAS, that is upregulated by Ang II and by systemic low grade inflammation. Lymphocyte can cross cerebral barrier and are involved in the immuno-mediated cerebral inflammation associated to brain subcortical damage. We are investigated whether in patients with brain subcortical vascular changes a selective Ang II–driven up-regulation of T-cell RAS occurs.

T Cell-Based RAS Activity and Insulin Levels in Obese Subjects with Low Grade Inflammation / mirella coppo, marco chiostri, loredana poggesi, pietro amedeo modesti, maria boddi. - In: THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES. - ISSN 0002-9629. - ELETTRONICO. - ?:(In corso di stampa), pp. 0-0. [DOI: 10.1016/j.amjms.2021.09.003]

T Cell-Based RAS Activity and Insulin Levels in Obese Subjects with Low Grade Inflammation

mirella coppo
Membro del Collaboration Group
;
loredana poggesi
Membro del Collaboration Group
;
pietro amedeo modesti
Membro del Collaboration Group
;
maria boddi
Membro del Collaboration Group
In corso di stampa

Abstract

Experimental evidence is growing that in patients with brain subcortical vascular changes a major role is played by angiotensin (Ang)II-mediated inflammation, also supported by reported positive effects of Ang II antagonists. Human cerebral renin angiotensin system (RAS) cannot be directly investigated and Ang II does not cross cerebral barrier. A cell-based RAS was shown in T-lymphocyte able to sustain an autonomous Ang II synthesis independently of circulating and tissue RAS, that is upregulated by Ang II and by systemic low grade inflammation. Lymphocyte can cross cerebral barrier and are involved in the immuno-mediated cerebral inflammation associated to brain subcortical damage. We are investigated whether in patients with brain subcortical vascular changes a selective Ang II–driven up-regulation of T-cell RAS occurs.
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Goal 3: Good health and well-being
mirella coppo, marco chiostri, loredana poggesi, pietro amedeo modesti, maria boddi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/1258409
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