We used intracellular microelectrodes to study the effect of histamine on oscillatory afterpotentials (OAPs). OAPs were induced by exposing cardiac Purkinje fibers to barium (10(-5) M) and to strophanthidin (3 X 10(-7) M). Histamine consistently increased the amplitude of the barium-induced OAPs. Similar results were obtained in strophanthidin-treated preparations: histamine, in fact, was able to increase the OAPs amplitude and eventually to induce triggered activity. The effect of histamine was antagonized by cimetidine (10(-5) M). The possible role of the OAPs in the arrhythmogenic action of histamine is discussed.

Role of the oscillatory afterpotentials in the arrhytmogenic action of histamine / AMERINI S.; F. FUSI; MUGELLI A.. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - STAMPA. - 16:(1985), pp. 219-221. [10.1007/BF01983144]

Role of the oscillatory afterpotentials in the arrhytmogenic action of histamine.

FUSI, FRANCO;MUGELLI, ALESSANDRO
1985

Abstract

We used intracellular microelectrodes to study the effect of histamine on oscillatory afterpotentials (OAPs). OAPs were induced by exposing cardiac Purkinje fibers to barium (10(-5) M) and to strophanthidin (3 X 10(-7) M). Histamine consistently increased the amplitude of the barium-induced OAPs. Similar results were obtained in strophanthidin-treated preparations: histamine, in fact, was able to increase the OAPs amplitude and eventually to induce triggered activity. The effect of histamine was antagonized by cimetidine (10(-5) M). The possible role of the OAPs in the arrhythmogenic action of histamine is discussed.
1985
16
219
221
AMERINI S.; F. FUSI; MUGELLI A.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/209866
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