We used intracellular microelectrodes to study the effect of histamine on oscillatory afterpotentials (OAPs). OAPs were induced by exposing cardiac Purkinje fibers to barium (10(-5) M) and to strophanthidin (3 X 10(-7) M). Histamine consistently increased the amplitude of the barium-induced OAPs. Similar results were obtained in strophanthidin-treated preparations: histamine, in fact, was able to increase the OAPs amplitude and eventually to induce triggered activity. The effect of histamine was antagonized by cimetidine (10(-5) M). The possible role of the OAPs in the arrhythmogenic action of histamine is discussed.
Role of the oscillatory afterpotentials in the arrhytmogenic action of histamine / AMERINI S.; F. FUSI; MUGELLI A.. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - STAMPA. - 16:(1985), pp. 219-221. [10.1007/BF01983144]
Role of the oscillatory afterpotentials in the arrhytmogenic action of histamine.
FUSI, FRANCO;MUGELLI, ALESSANDRO
1985
Abstract
We used intracellular microelectrodes to study the effect of histamine on oscillatory afterpotentials (OAPs). OAPs were induced by exposing cardiac Purkinje fibers to barium (10(-5) M) and to strophanthidin (3 X 10(-7) M). Histamine consistently increased the amplitude of the barium-induced OAPs. Similar results were obtained in strophanthidin-treated preparations: histamine, in fact, was able to increase the OAPs amplitude and eventually to induce triggered activity. The effect of histamine was antagonized by cimetidine (10(-5) M). The possible role of the OAPs in the arrhythmogenic action of histamine is discussed.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.