Alkanoyl-6-O-ascorbic acid esters are easily obtained from vitamin C, and produce self-assembled aggregates in water solutions, with an inner hydrophobic pool surrounded by an external hydrophilic shell. Compared to ascorbic acid, their solubility in ails and fats is greatly enhanced, while the peculiar antioxidant activity is retained in the polar head groups of such surfactants. In virtue of their amphiphilic nature, ascorbic acid-based supramolecular systems can dissolve relevant amounts, of hydrophobic, poorly water soluble chemicals such as drugs, vitamins, and so on, and at the same time they provide a suitable shield against oxidative deterioration of valuable materials. In this article we report our study on the self-assembling properties of octanoyl-6-O-ascorbic acid in water, and on the solubilization of some lipophilic molecules in its dispersions.

Solubilization of hydrophobic drugs in octanoyl-6-O-ascorbic acid micellar dispersions / Palma, S.; Manzo, R. H.; Allemandi, D.; Fratoni, L.; LO NOSTRO, Pierandrea. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - STAMPA. - 91:(2002), pp. 1810-1816. [10.1002/jps.10180]

Solubilization of hydrophobic drugs in octanoyl-6-O-ascorbic acid micellar dispersions

LO NOSTRO, PIERANDREA
2002

Abstract

Alkanoyl-6-O-ascorbic acid esters are easily obtained from vitamin C, and produce self-assembled aggregates in water solutions, with an inner hydrophobic pool surrounded by an external hydrophilic shell. Compared to ascorbic acid, their solubility in ails and fats is greatly enhanced, while the peculiar antioxidant activity is retained in the polar head groups of such surfactants. In virtue of their amphiphilic nature, ascorbic acid-based supramolecular systems can dissolve relevant amounts, of hydrophobic, poorly water soluble chemicals such as drugs, vitamins, and so on, and at the same time they provide a suitable shield against oxidative deterioration of valuable materials. In this article we report our study on the self-assembling properties of octanoyl-6-O-ascorbic acid in water, and on the solubilization of some lipophilic molecules in its dispersions.
2002
91
1810
1816
Palma, S.; Manzo, R. H.; Allemandi, D.; Fratoni, L.; LO NOSTRO, Pierandrea
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/213008
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