The effect of off-resonance irradiation on the water proton NMR signal intensity has been investigated as follows: (a) in the presence of a paramagnetic probe like manganese(l1); (b) in the presence of bovine serum albumin (BSA) and two gadolinium( lll) complexes, Gd-DTPA and Gd-BOPTA; (c) in the presence of cross-linked BSA and the two above-mentioned gadolinium(lll) complexes. The experimental data have been rationalized on the basis of the available theoretical models. The effectiveness of the two complexes as contrast agents for MRI has been predicted. It is shown that contrast agents providing comparable longitudinal and transverse relaxation rate enhancements are those of general interest for off-resonance magnetization transfer-MRI.

Off-resonance experiments and contrast agents to improve magnetic resonance imaging / BERTINI I.; LUCHINAT C.; G. PARIGI; QUACQUARINI G.; MARZOLA P.; CAVAGNA F.M.. - In: MAGNETIC RESONANCE IN MEDICINE. - ISSN 0740-3194. - STAMPA. - 39:(1998), pp. 124-131.

Off-resonance experiments and contrast agents to improve magnetic resonance imaging

BERTINI, IVANO;LUCHINAT, CLAUDIO;PARIGI, GIACOMO;
1998

Abstract

The effect of off-resonance irradiation on the water proton NMR signal intensity has been investigated as follows: (a) in the presence of a paramagnetic probe like manganese(l1); (b) in the presence of bovine serum albumin (BSA) and two gadolinium( lll) complexes, Gd-DTPA and Gd-BOPTA; (c) in the presence of cross-linked BSA and the two above-mentioned gadolinium(lll) complexes. The experimental data have been rationalized on the basis of the available theoretical models. The effectiveness of the two complexes as contrast agents for MRI has been predicted. It is shown that contrast agents providing comparable longitudinal and transverse relaxation rate enhancements are those of general interest for off-resonance magnetization transfer-MRI.
1998
39
124
131
BERTINI I.; LUCHINAT C.; G. PARIGI; QUACQUARINI G.; MARZOLA P.; CAVAGNA F.M.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/219893
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