Objective. The prevalence of thyroid cancer in a series of unselected HCVre l ated mixed cryog l o bulinemic pa - tients was investigated in comparison with a control group. Methods. Among 107 consecutive patients with mixed cryog l o bu l i n e m i a (MC), 94 were eligible for the study. A c o n t rol group was obtained from a sam - ple of the general population (2,401 s u b j e c t s ) , age > 50 ye a rs , who had u n d e rgone thy roid ultra s o n ograp hy (582 subjects); 5 sex-matched controls were randomly assigned to each MC p atient (470 individuals). The mean age was similar in the MC patients and controls (64.2 ± 10.0 vs. 63.4 ± 7.0). Results. The prevalence of thyroid no - dules was higher, although not signifi - cantly so, in control subjects than in MC patients (65.3 vs. 54.8%). Two patients with papillary thyroid cancer were found in the MC series, while no case was observed among controls (p = 0.001, chi-square P value; p = 0.02, Fisher’s exact test). In both MC pa - tients with pap i l l a ry thy roid cancer lymphocytic infiltration was observed in the thyroid tissue. Conclusions. The possible association between HCV-related MC and thyroid cancer indicates that a careful moni - toring of the thyroid would be oppor - tune during the clinical follow-up of H C V- a s s o c i ated MC pat i e n t s , e s p e - cially in those with signs of thyroid autoimmune disorders.
Thyroid cancer in HCV-related mixed cryoglobulinemia patients / A. Antonelli; C. Ferri; P. Fallahi; C. Nesti; A.L. Zignego; M. Maccheroni. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 20(5):(2002), pp. 693-696.
Thyroid cancer in HCV-related mixed cryoglobulinemia patients
ZIGNEGO, ANNA LINDA;
2002
Abstract
Objective. The prevalence of thyroid cancer in a series of unselected HCVre l ated mixed cryog l o bulinemic pa - tients was investigated in comparison with a control group. Methods. Among 107 consecutive patients with mixed cryog l o bu l i n e m i a (MC), 94 were eligible for the study. A c o n t rol group was obtained from a sam - ple of the general population (2,401 s u b j e c t s ) , age > 50 ye a rs , who had u n d e rgone thy roid ultra s o n ograp hy (582 subjects); 5 sex-matched controls were randomly assigned to each MC p atient (470 individuals). The mean age was similar in the MC patients and controls (64.2 ± 10.0 vs. 63.4 ± 7.0). Results. The prevalence of thyroid no - dules was higher, although not signifi - cantly so, in control subjects than in MC patients (65.3 vs. 54.8%). Two patients with papillary thyroid cancer were found in the MC series, while no case was observed among controls (p = 0.001, chi-square P value; p = 0.02, Fisher’s exact test). In both MC pa - tients with pap i l l a ry thy roid cancer lymphocytic infiltration was observed in the thyroid tissue. Conclusions. The possible association between HCV-related MC and thyroid cancer indicates that a careful moni - toring of the thyroid would be oppor - tune during the clinical follow-up of H C V- a s s o c i ated MC pat i e n t s , e s p e - cially in those with signs of thyroid autoimmune disorders.File | Dimensione | Formato | |
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