The involvement of Gi proteins in the modulation of pain perception has been widely established, and mutations in G-proteins have already been identified as the aetiopathological cause of human diseases. The aim of the present study was to determine whether a deficiency or a hypofunctionality of the Gi proteins occurred in primary headache. The functionality and the level of expression of Gi proteins were investigated in lymphocytes from migraine without aura, migraine with aura and cluster headache sufferers. A reduced capability to inhibit forskolin-stimulated adenylyl cyclase activity in headache patients was observed. Migraine patients also showed basal adenosine cAMP levels about four times higher than controls. The reduced activity of Gi proteins seems not to be related to a reduction of protein levels since no significant reduction of the Gia subunits was observed. These results indicate Gi protein hypofunctionality as an aetiopathogenic mechanism in migraine and cluster headache.

HYPOFUNCTIONALITY OF GI PROTEINS AS AETIOPHATOGENETIC MECHANISM FOR MIGRAINE AND CLUSTER HEADACHE / N. GALEOTTI; C. GHELARDINI; M. ZOPPI; E. DEL BENE; L. RAIMONDI; E. BENEFORTI; A. BARTOLINI. - In: CEPHALALGIA. - ISSN 0333-1024. - STAMPA. - 21:(2001), pp. 38-45. [10.1046/j.1468-2982.2001.00142.x]

HYPOFUNCTIONALITY OF GI PROTEINS AS AETIOPHATOGENETIC MECHANISM FOR MIGRAINE AND CLUSTER HEADACHE

GALEOTTI, NICOLETTA;GHELARDINI, CARLA;ZOPPI, MASSIMO;DEL BENE, ENRICO;RAIMONDI, LAURA;BENEFORTI, ELISABETTA;BARTOLINI, ALESSANDRO
2001

Abstract

The involvement of Gi proteins in the modulation of pain perception has been widely established, and mutations in G-proteins have already been identified as the aetiopathological cause of human diseases. The aim of the present study was to determine whether a deficiency or a hypofunctionality of the Gi proteins occurred in primary headache. The functionality and the level of expression of Gi proteins were investigated in lymphocytes from migraine without aura, migraine with aura and cluster headache sufferers. A reduced capability to inhibit forskolin-stimulated adenylyl cyclase activity in headache patients was observed. Migraine patients also showed basal adenosine cAMP levels about four times higher than controls. The reduced activity of Gi proteins seems not to be related to a reduction of protein levels since no significant reduction of the Gia subunits was observed. These results indicate Gi protein hypofunctionality as an aetiopathogenic mechanism in migraine and cluster headache.
2001
21
38
45
N. GALEOTTI; C. GHELARDINI; M. ZOPPI; E. DEL BENE; L. RAIMONDI; E. BENEFORTI; A. BARTOLINI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/2280
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