We describe a mass-spectrometric method based on the fast atom bombardment ionization technique in the negative-ion mode for measuring pregnanediol-3a-glucuronide in diluted urine from women. The procedure requires addition of testosterone-17beta-D-glucuronide (2.5 microg/25 microL) to the urine sample as internal standard, and the sample is added directly to the fast atom bombardment target with no further manipulation. We have assessed and evaluated the method by the traditional criteria of reliability.
Pregnanediol-3 alpha-glucuronide measured in diluted urine by mass spectrometry with fast atom bombardment/negative-ion ionization / G. MONETI; G. AGATI; M.G. GIOVANNINI; M. PAZZAGLI; R. SALERNO; G. MESSERI; M. SERIO. - In: CLINICAL CHEMISTRY. - ISSN 0009-9147. - ELETTRONICO. - 31:(1985), pp. 46-49.
Pregnanediol-3 alpha-glucuronide measured in diluted urine by mass spectrometry with fast atom bombardment/negative-ion ionization
MONETI, GLORIANO;GIOVANNINI, MARIA GRAZIA;PAZZAGLI, MARIO;
1985
Abstract
We describe a mass-spectrometric method based on the fast atom bombardment ionization technique in the negative-ion mode for measuring pregnanediol-3a-glucuronide in diluted urine from women. The procedure requires addition of testosterone-17beta-D-glucuronide (2.5 microg/25 microL) to the urine sample as internal standard, and the sample is added directly to the fast atom bombardment target with no further manipulation. We have assessed and evaluated the method by the traditional criteria of reliability.
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