To understand the short-term dynamics of the circulating T cell receptor V beta (TCRBV) repertoire in relapsing-remitting multiple sclerosis (MS), we monitored the TCRBV profiles of untreated MS patients and healthy controls. Expansions of TCRBV genes in MS patients were significantly more frequent than in controls (P<0.001), were predominantly oligoclonal (80%) and were significantly correlated with immune responses to myelin basic protein (MBP) (P<0.02) and with inflammatory disease activity detected by magnetic resonance imaging (MRI) (P<0.05). Autoreactive T cell responses against myelin antigens may be implicated in perturbations of TCR repertoire in untreated MS patients, detectable even in the absence of clinically evident manifestations.

Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing-remitting MS / MURARO P.A; BONANNI L; MAZZANTI B; PANTALONE A; TRAGGIAI E; MASSACESI L; VERGELLI M; GAMBI D;. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 127:(2002), pp. 149-159. [10.1016/S0165-5728(02)00105-4]

Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing-remitting MS.

MAZZANTI, BENEDETTA;MASSACESI, LUCA;VERGELLI, MARCO;
2002

Abstract

To understand the short-term dynamics of the circulating T cell receptor V beta (TCRBV) repertoire in relapsing-remitting multiple sclerosis (MS), we monitored the TCRBV profiles of untreated MS patients and healthy controls. Expansions of TCRBV genes in MS patients were significantly more frequent than in controls (P<0.001), were predominantly oligoclonal (80%) and were significantly correlated with immune responses to myelin basic protein (MBP) (P<0.02) and with inflammatory disease activity detected by magnetic resonance imaging (MRI) (P<0.05). Autoreactive T cell responses against myelin antigens may be implicated in perturbations of TCR repertoire in untreated MS patients, detectable even in the absence of clinically evident manifestations.
2002
127
149
159
MURARO P.A; BONANNI L; MAZZANTI B; PANTALONE A; TRAGGIAI E; MASSACESI L; VERGELLI M; GAMBI D;
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/254556
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