The post-mortem stability of some brain enzymes was studied. Over the time period under examination, the cytoplasmic enzymes investigated underwent a decisive decay, hexokinase being the most labile and acylphosphatase the most stable. On the other hand, structured activities such as Na+, K+-ATPase and Ca2+, Mg2+-ATPase showed an apparent transitory increase. The differences in post-mortem stability of soluble enzymes could be ascribed, at least in part, to their different susceptibility toward proteolytic activities, as suggested by the electrophoretic results.
Post-mortem modifications of the specific activity of some brain enzymes / G.LIGURI ; P.NASSI ; N.TADDEI ; C. NEDIANI. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 85:(1988), pp. 244-248.
Post-mortem modifications of the specific activity of some brain enzymes
LIGURI, GIANFRANCO;NASSI, PAOLO ANTONIO;TADDEI, NICCOLO';NEDIANI, CHIARA
1988
Abstract
The post-mortem stability of some brain enzymes was studied. Over the time period under examination, the cytoplasmic enzymes investigated underwent a decisive decay, hexokinase being the most labile and acylphosphatase the most stable. On the other hand, structured activities such as Na+, K+-ATPase and Ca2+, Mg2+-ATPase showed an apparent transitory increase. The differences in post-mortem stability of soluble enzymes could be ascribed, at least in part, to their different susceptibility toward proteolytic activities, as suggested by the electrophoretic results.
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