Objective: To evaluate the role of factor V Leiden, prothrombin G20210A polymorphism, plasminogen activator inhibitor type 1 (PAI-1) 4G/5G polymorphism, PAI-1, homocysteine, and lipoprotein ( a) ( Lp( a)) in the occurrence of major adverse cardiac events ( MACE) in patients with acute coronary syndromes who underwent coronary stenting. Design: 520 patients ( 375 men and 145 women) with acute coronary syndromes and 520 age and sex matched controls were enrolled. MACE were recorded for 109 patients. Heterozygosity for factor V Leiden, prothrombin G20210A polymorphism, and 4G/5G polymorphism did not significantly differ between patients with and without MACE. A significantly higher percentage of patients with increased homocysteine ( 28% v 19%, p< 0.001) and PAI-1 concentrations (25% v 16%, p< 0.001) had MACE with respect to those who did not. In Kaplan-Meier survival analysis, the overall risk of MACE was significantly higher among patients with increased PAI-1 ( p = 0.006) and homocysteine concentrations ( p = 0.04). Cox regression analysis adjusted for age, sex, traditional cardiovascular risk factors, renal function, systolic left ventricular function, the number of stenosed vessels, and history of percutaneous coronary intervention or coronary artery bypass grafting showed that homocysteine ( odds ratio 7.5, 95% confidence interval (CI) 1.1 to 57.7, p< 0.05) and PAI-1 concentrations ( odds ratio 5.3, 95% CI 1.2 to 23.8, p< 0.05) within the fifth quintile ( with respect to the first) were significant and independent risk factors for the future occurrence of MACE. Conclusions: Increased PAI-1 and homocysteine concentrations are independent risk factors for MACE after successful coronary stenting, whereas Lp( a) and thrombophilic polymorphisms are not predictive.

PAI-1 and homocysteine, but not lipoprotein (a) nor thrombophilic polymorphism, are associated with the occurrence of major adverse cardiac events after successful coronary stenting / R. MARCUCCI; D. BROGI; F. SOFI; C. GIGLIOLI; S. VALENTE; A. ALESSANDRELLO LIOTTA; M. LENTI; A.M. GORI; D. PRISCO; R. ABBATE; G.F. GENSINI. - In: HEART. - ISSN 1355-6037. - STAMPA. - 92:(2006), pp. 377-381. [10.1136/hrt.2005.061895]

PAI-1 and homocysteine, but not lipoprotein (a) nor thrombophilic polymorphism, are associated with the occurrence of major adverse cardiac events after successful coronary stenting

MARCUCCI, ROSSELLA;SOFI, FRANCESCO;GORI, ANNA MARIA;PRISCO, DOMENICO;ABBATE, ROSANNA;GENSINI, GIAN FRANCO
2006

Abstract

Objective: To evaluate the role of factor V Leiden, prothrombin G20210A polymorphism, plasminogen activator inhibitor type 1 (PAI-1) 4G/5G polymorphism, PAI-1, homocysteine, and lipoprotein ( a) ( Lp( a)) in the occurrence of major adverse cardiac events ( MACE) in patients with acute coronary syndromes who underwent coronary stenting. Design: 520 patients ( 375 men and 145 women) with acute coronary syndromes and 520 age and sex matched controls were enrolled. MACE were recorded for 109 patients. Heterozygosity for factor V Leiden, prothrombin G20210A polymorphism, and 4G/5G polymorphism did not significantly differ between patients with and without MACE. A significantly higher percentage of patients with increased homocysteine ( 28% v 19%, p< 0.001) and PAI-1 concentrations (25% v 16%, p< 0.001) had MACE with respect to those who did not. In Kaplan-Meier survival analysis, the overall risk of MACE was significantly higher among patients with increased PAI-1 ( p = 0.006) and homocysteine concentrations ( p = 0.04). Cox regression analysis adjusted for age, sex, traditional cardiovascular risk factors, renal function, systolic left ventricular function, the number of stenosed vessels, and history of percutaneous coronary intervention or coronary artery bypass grafting showed that homocysteine ( odds ratio 7.5, 95% confidence interval (CI) 1.1 to 57.7, p< 0.05) and PAI-1 concentrations ( odds ratio 5.3, 95% CI 1.2 to 23.8, p< 0.05) within the fifth quintile ( with respect to the first) were significant and independent risk factors for the future occurrence of MACE. Conclusions: Increased PAI-1 and homocysteine concentrations are independent risk factors for MACE after successful coronary stenting, whereas Lp( a) and thrombophilic polymorphisms are not predictive.
2006
92
377
381
R. MARCUCCI; D. BROGI; F. SOFI; C. GIGLIOLI; S. VALENTE; A. ALESSANDRELLO LIOTTA; M. LENTI; A.M. GORI; D. PRISCO; R. ABBATE; G.F. GENSINI
File in questo prodotto:
File Dimensione Formato  
PAI, Omo and MACE.pdf

Accesso chiuso

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Tutti i diritti riservati
Dimensione 195.43 kB
Formato Adobe PDF
195.43 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/256111
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 49
  • ???jsp.display-item.citation.isi??? 46
social impact