SPHINGOSINE 1-PHOSPHATE REGULATES CYTOSKELETON DYNAMICS: IMPLICATIONS IN ITS BIOLOGICAL RESPONSE.

The bioactive sphingolipid sphingosine 1-phosphate (S1P) elicits robust cytoskeletal rearrangement in a large variety of cell systems, mainly acting through a panel of specific cell surface receptors, named S1P receptors. Recent studies have begun to delineate the molecular mechanisms involved in the complex process responsible for cytoskeletal rearrangement following S1P ligation to its receptors. Notably, changes of cell shape and/or motility induced by S1P via cytoskeletal remodelling are functional to the biological action exerted by S1P which appears to be highly cellspecific. This review focuses on the current knowledge of the regulatory mechanisms of cytoskeleton dynamics elicited by S1P, with special emphasis on the relationship between cytoskeletal remodelling and the biological effects evoked by the sphingolipid in various cell types.