Pacemaker channels play a major role in the generation of sinoatrial rhythmic activity. However, their expression is not confined to specialized myocardial cells, such as primary and subsidiary pacemakers. Electrophysiological and molecular data collected over the last ten years have demonstrated that f-channels are also present in non-pacemaker cardiomyocytes, and become upregulated in cardiac hypertrophy and failure. Mislocalized expression and/or overexpression of f-channels are a consequence of electrophysiological remodeling and, from a clinical point of view, may represent an arrhythmogenic mechanism in heart failure, a condition associated with a high risk for sudden cardiac death. The potential arrhythmogenic role of I-f and the availability of selective f-channel blockers cause I-f to be a suitable therapeutic target in heart disease.

I(f) in non-pacemaker cells: role and pharmacological implications / E. CERBAI; A. MUGELLI. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 53:(2006), pp. 416-423. [10.1016/j.phrs.2006.03.015]

I(f) in non-pacemaker cells: role and pharmacological implications.

CERBAI, ELISABETTA
;
MUGELLI, ALESSANDRO
2006

Abstract

Pacemaker channels play a major role in the generation of sinoatrial rhythmic activity. However, their expression is not confined to specialized myocardial cells, such as primary and subsidiary pacemakers. Electrophysiological and molecular data collected over the last ten years have demonstrated that f-channels are also present in non-pacemaker cardiomyocytes, and become upregulated in cardiac hypertrophy and failure. Mislocalized expression and/or overexpression of f-channels are a consequence of electrophysiological remodeling and, from a clinical point of view, may represent an arrhythmogenic mechanism in heart failure, a condition associated with a high risk for sudden cardiac death. The potential arrhythmogenic role of I-f and the availability of selective f-channel blockers cause I-f to be a suitable therapeutic target in heart disease.
2006
53
416
423
E. CERBAI; A. MUGELLI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/26577
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