The Kq channel antagonists, glucose 100 mg per mouse i.c.v.., tetraethylammonium 1 mg per mouse i.c.v.. and apamin 1 ng per mouse i.c.v.., reduced food intake of mice comparably to the two anorectic drugs, amphetamine 10 mg per mouse i.c.v.. and cocaine 50 mg per mouse i.c.v... Conversely, the Kq channel openers, minoxidil 5 mg per mouse i.c.v.. and pinacidil 10 mg per mouse i.c.v.., elicited an orectic effect of the same intensity as that induced by 2-deoxyglucose 200 mg per mouse i.c.v.., aurothioglucose 200 mg per mouse i.c.v.. and neuropeptide Y 0.5 mg per mouse i.c.v... The antisense oligodeoxyribonucleotide 1–3 nmol per injection. to mKv1.1 gene produced, at 72 h, a dose-dependent increase in food intake. A quantitative reverse transcription-polymerase chain reaction RT-PCR. study demonstrated a reduction in cerebral mRNA levels only in the antisense oligodeoxyribonucleotide-treated group, indicating the absence of a sequence-independent action. Mice receiving the Kq channel modulators or antisense oligodeoxyribonucleotide had unmodified motor coordination and inspection activity as revealed, respectively, by the rotarod and hole-board tests. The integrity and functionality of central Kq channels appears, therefore, to be fundamental in the regulation of food intake by mice.

Effect of K+ channel modulation on mouse feeding behaviour / GHELARDINI C; GALEOTTI N; PECORI VETTORI A; CAPACCIOLI S; QUATTRONE A; A. BARTOLINI. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 329:(1997), pp. 1-8. [10.1016/S0014-2999(97)10102-9]

Effect of K+ channel modulation on mouse feeding behaviour

GHELARDINI, CARLA;GALEOTTI, NICOLETTA;CAPACCIOLI, SERGIO;QUATTRONE, ALESSANDRO;BARTOLINI, ALESSANDRO
1997

Abstract

The Kq channel antagonists, glucose 100 mg per mouse i.c.v.., tetraethylammonium 1 mg per mouse i.c.v.. and apamin 1 ng per mouse i.c.v.., reduced food intake of mice comparably to the two anorectic drugs, amphetamine 10 mg per mouse i.c.v.. and cocaine 50 mg per mouse i.c.v... Conversely, the Kq channel openers, minoxidil 5 mg per mouse i.c.v.. and pinacidil 10 mg per mouse i.c.v.., elicited an orectic effect of the same intensity as that induced by 2-deoxyglucose 200 mg per mouse i.c.v.., aurothioglucose 200 mg per mouse i.c.v.. and neuropeptide Y 0.5 mg per mouse i.c.v... The antisense oligodeoxyribonucleotide 1–3 nmol per injection. to mKv1.1 gene produced, at 72 h, a dose-dependent increase in food intake. A quantitative reverse transcription-polymerase chain reaction RT-PCR. study demonstrated a reduction in cerebral mRNA levels only in the antisense oligodeoxyribonucleotide-treated group, indicating the absence of a sequence-independent action. Mice receiving the Kq channel modulators or antisense oligodeoxyribonucleotide had unmodified motor coordination and inspection activity as revealed, respectively, by the rotarod and hole-board tests. The integrity and functionality of central Kq channels appears, therefore, to be fundamental in the regulation of food intake by mice.
1997
329
1
8
GHELARDINI C; GALEOTTI N; PECORI VETTORI A; CAPACCIOLI S; QUATTRONE A; A. BARTOLINI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/309786
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