Unprotected pyrimidine bases were used in Mitsunobu reaction to afford in high yield new substituted pyrrolidines. The reaction is chemo-, regio- and stereoselective affording exclusively N-1 alkylated derivatives of (3S)-N-benzyl-3-hydroxypyrrolidine and (3S,4S)-N-benzyl-3,4-dihydroxypyrrolidine.
Chemo-, Regio- and Stereoselective Mitsunobu Reaction of Unprotected Pyrimidine Bases with Hydroxypyrrolidines / B. Richichi; S. Cicchi; U. Chiacchio; G. Romeob; A. Brandi. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 43:(2002), pp. 4013-4015. [10.1016/S0040-4039(02)00712-8]
Chemo-, Regio- and Stereoselective Mitsunobu Reaction of Unprotected Pyrimidine Bases with Hydroxypyrrolidines.
RICHICHI, BARBARA;CICCHI, STEFANO;BRANDI, ALBERTO
2002
Abstract
Unprotected pyrimidine bases were used in Mitsunobu reaction to afford in high yield new substituted pyrrolidines. The reaction is chemo-, regio- and stereoselective affording exclusively N-1 alkylated derivatives of (3S)-N-benzyl-3-hydroxypyrrolidine and (3S,4S)-N-benzyl-3,4-dihydroxypyrrolidine.
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