As a continuation of previous research on anticholinergic drugs derived from 2,2-diphenyl-2-ethylthioacetic acid, several compounds were synthesized and theirantimuscarinic activity on M1-M4 receptor subtypes was evaluated by functional tests and binding experiments. One of the compounds obtained showed unexpected agonistic activity in functional experiments on M2 receptors.

Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists / Scapecchi, Serena; Marucci, G.; Matucci, Rosanna; Angeli, P.; Bellucci, Cristina; Buccioni, M.; Dei, Silvia; Gualtieri, Fulvio; Manetti, Dina; Romanelli, MARIA NOVELLA; Teodori, Elisabetta. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 9:(2001), pp. 1165-1174.

Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.

SCAPECCHI, SERENA;MATUCCI, ROSANNA;BELLUCCI, CRISTINA;DEI, SILVIA;GUALTIERI, FULVIO;MANETTI, DINA;ROMANELLI, MARIA NOVELLA;TEODORI, ELISABETTA
2001

Abstract

As a continuation of previous research on anticholinergic drugs derived from 2,2-diphenyl-2-ethylthioacetic acid, several compounds were synthesized and theirantimuscarinic activity on M1-M4 receptor subtypes was evaluated by functional tests and binding experiments. One of the compounds obtained showed unexpected agonistic activity in functional experiments on M2 receptors.
2001
9
1165
1174
Scapecchi, Serena; Marucci, G.; Matucci, Rosanna; Angeli, P.; Bellucci, Cristina; Buccioni, M.; Dei, Silvia; Gualtieri, Fulvio; Manetti, Dina; Romanelli, MARIA NOVELLA; Teodori, Elisabetta
File in questo prodotto:
File Dimensione Formato  
Bioorg_sere_01.pdf

Accesso chiuso

Descrizione: articolo
Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 221.08 kB
Formato Adobe PDF
221.08 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/310377
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 10
social impact