The enantiomers of 3-alpha-tropyl 2-(phenylthio)butyrate (SM(32), 1) were prepared by chiral synthesis and tested for analgesic, cognition-enhancing and ACh-releasing properties. They show enantioselectivity in some of the tests, the eutomer being related in configuration to R-(+)-hyoscyamine
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent / M. ROMANELLI; A. BARTOLINI; C. BERTUCCI; S. DEI; C. GHELARDINI; M. GIOVANNINI; F. GUALTIERI; G. PEPEU; S. SCAPECCHI; E. TEODORI;. - In: CHIRALITY. - ISSN 0899-0042. - STAMPA. - 8:(1996), pp. 579-584. [10.1002/(SICI)1520-636X(1996)8:8<579::AID-CHIR7>3.0.CO;2-4]
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent.
ROMANELLI, MARIA NOVELLA;BARTOLINI, ALESSANDRO;DEI, SILVIA;GHELARDINI, CARLA;GIOVANNINI, MARIA GRAZIA;GUALTIERI, FULVIO;PEPEU, GIANCARLO;SCAPECCHI, SERENA;TEODORI, ELISABETTA
1996
Abstract
The enantiomers of 3-alpha-tropyl 2-(phenylthio)butyrate (SM(32), 1) were prepared by chiral synthesis and tested for analgesic, cognition-enhancing and ACh-releasing properties. They show enantioselectivity in some of the tests, the eutomer being related in configuration to R-(+)-hyoscyamine
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