In the present study, we demonstrated that the urokinase-type plasminogen activator (u-PA) induced neovascular growth in the avascular rabbit cornea and dose-dependently promoted growth, chemotaxis, and matrix invasion of cultured endothelial cells.
Urokinase-dependent angiogenesis in vitro and diacylglycerol production are blocked by antisense oligonucleotides against the urokinase receptor / G. FIBBI; R. CALDINI; M. CHEVANNE; M. PUCCI; N. SCHIAVONE; L. MORBIDELLI; M. DEL ROSSO; M. ZICHE; A. PARENTI; M. GRANGER. - In: LABORATORY INVESTIGATION. - ISSN 0023-6837. - STAMPA. - 78:(1998), pp. 1109-1119.
Urokinase-dependent angiogenesis in vitro and diacylglycerol production are blocked by antisense oligonucleotides against the urokinase receptor
FIBBI, GABRIELLA;CALDINI, RICCARDO;CHEVANNE, MARTA;PUCCI, MARCO;SCHIAVONE, NICOLA;DEL ROSSO, MARIO;ZICHE, MARINA;PARENTI, ASTRID;
1998
Abstract
In the present study, we demonstrated that the urokinase-type plasminogen activator (u-PA) induced neovascular growth in the avascular rabbit cornea and dose-dependently promoted growth, chemotaxis, and matrix invasion of cultured endothelial cells.
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