Primary cutaneous B-cell lymphoma (CBCL) are B-cell non-Hodgkin’s lymphoma primarily presenting in the skin without any detectable extracutaneous lesion despite careful and complete staging procedures. Previous studies of our group indicate that CBCL should be considered as a unique type of a low grade lymphoma4 In fact, CBCL have: 1. non aggressive clinical behavior (mostly loco-regional extension, good response to local treatments, low tendency to spread, and excellent prognosis); 2. uniform immunophenotypic (CD5-, CD10-) and genotypic features of neoplastic B-cells (lack of bcl-2 gene rearrangement), and 3. histologic evidence of centrocyte-like (monocytoid, parafollicular) cells in their whole morphologic spectrum, plasma cells, reactive lymphoid follicles and lymphoepithelial lesions. These typical features are strikingly similar to those described in so-called MALT (Mucosa-Associated Lymphoid Tissue) lymphoma, suggesting the interpretation of CBCL as the cutaneous counterpart of MALT lymphoma, i.e., Skin-Associated Lymphoid Tissue (SALT)-related B-cell lymphoma. The close clinical, histologic, immunologic, and genotypic similarities of CBCL and MALT-lymphoma with monocytoid/parafollicular lymphoma suggest the hypothesis of a common marginal cell origin for these neoplasms.

Architectural and antigenic features of follicular dendritic cells as a clue to the histogenesis of primary cutaneous B-cell lymphoma / M. MORI; M. SANTUCCI; N. PIMPINELLI. - STAMPA. - (1995), pp. 277-279. [10.1007/978-1-4615-1971-3_61]

Architectural and antigenic features of follicular dendritic cells as a clue to the histogenesis of primary cutaneous B-cell lymphoma

M. SANTUCCI;N. PIMPINELLI
1995

Abstract

Primary cutaneous B-cell lymphoma (CBCL) are B-cell non-Hodgkin’s lymphoma primarily presenting in the skin without any detectable extracutaneous lesion despite careful and complete staging procedures. Previous studies of our group indicate that CBCL should be considered as a unique type of a low grade lymphoma4 In fact, CBCL have: 1. non aggressive clinical behavior (mostly loco-regional extension, good response to local treatments, low tendency to spread, and excellent prognosis); 2. uniform immunophenotypic (CD5-, CD10-) and genotypic features of neoplastic B-cells (lack of bcl-2 gene rearrangement), and 3. histologic evidence of centrocyte-like (monocytoid, parafollicular) cells in their whole morphologic spectrum, plasma cells, reactive lymphoid follicles and lymphoepithelial lesions. These typical features are strikingly similar to those described in so-called MALT (Mucosa-Associated Lymphoid Tissue) lymphoma, suggesting the interpretation of CBCL as the cutaneous counterpart of MALT lymphoma, i.e., Skin-Associated Lymphoid Tissue (SALT)-related B-cell lymphoma. The close clinical, histologic, immunologic, and genotypic similarities of CBCL and MALT-lymphoma with monocytoid/parafollicular lymphoma suggest the hypothesis of a common marginal cell origin for these neoplasms.
1995
Dendritic Cells In Fundamental and Clinical Immunology
277
279
M. MORI; M. SANTUCCI; N. PIMPINELLI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/311421
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