Non-classical protein release independent of the ER-Golgi pathway has been reported for an increasing number of proteins lacking an N-terminal signal sequence. The export of FGH1 and IL-1α, two pro-angiogenic polypeptides, provides two such examples. In both cases, export is based on the Cu2+-dependent formation of multiprotein complexes containing the S100A13 protein and might involve translocation of the protein across the membrane as a 'molten globule'. FGF1 and IL-1α are involved in pathological processes such as restenosis and tumor formation. Inhibition of their export by Cu2+ chelators is thus an effective strategy for treatment of several diseases.
The non-classical export routes: FGF1 and IL1alpha point the way / I. PRUDOVSKY; A. MANDINOVA; R. SOLDI; C. BAGALA; I. GRAZIANI; M. LANDRISCINA; F. TARANTINI; M. DUARTE; S. BELLUM; H. DOHERTY; T. MACIAG. - In: JOURNAL OF CELL SCIENCE. - ISSN 0021-9533. - STAMPA. - 116:(2003), pp. 4871-4881.
The non-classical export routes: FGF1 and IL1alpha point the way.
TARANTINI, FRANCESCA;
2003
Abstract
Non-classical protein release independent of the ER-Golgi pathway has been reported for an increasing number of proteins lacking an N-terminal signal sequence. The export of FGH1 and IL-1α, two pro-angiogenic polypeptides, provides two such examples. In both cases, export is based on the Cu2+-dependent formation of multiprotein complexes containing the S100A13 protein and might involve translocation of the protein across the membrane as a 'molten globule'. FGF1 and IL-1α are involved in pathological processes such as restenosis and tumor formation. Inhibition of their export by Cu2+ chelators is thus an effective strategy for treatment of several diseases.File | Dimensione | Formato | |
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