Two members of a new class of heterocyclic ketones with aspirocyclopropane groups, obtained by 1,3-dipolar cycloaddition to bicyclopropylidene and thermal rearrangement of the adducts, have shown moderate DNA cleaving activity on a pUCI9 DNA plasmid These compounds have structural analogies with the potent carcinogenic sesquiterpenes Ptaquiloside and llludin.
Heterocyclic Ketones with α-Spirocyclopropane Groups Possessing DNA Cleaving Activity / A. GOTI; B. ANICHINI; A. BRANDI; A. DE MEIJERE; L. CITTI; S. NEVISCHI. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 36:(1995), pp. 5811-5814.
Heterocyclic Ketones with α-Spirocyclopropane Groups Possessing DNA Cleaving Activity
GOTI, ANDREA;ANICHINI, BEATRICE;BRANDI, ALBERTO;
1995
Abstract
Two members of a new class of heterocyclic ketones with aspirocyclopropane groups, obtained by 1,3-dipolar cycloaddition to bicyclopropylidene and thermal rearrangement of the adducts, have shown moderate DNA cleaving activity on a pUCI9 DNA plasmid These compounds have structural analogies with the potent carcinogenic sesquiterpenes Ptaquiloside and llludin.
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