This article reviews relevant pharmacologic and clinical information gathered for valproate since it was introduced into clinical practice 37 years ago and the application of this information for the treatment of childhood epilepsy. Valproate is available for oral and parenteral use. Oral forms are almost completely bioavailable but the rate of absorption varies between formulations.
Valproate as a mainstay of therapy for pediatric epilepsy / R.GUERRINI. - In: PAEDIATRIC DRUGS. - ISSN 1174-5878. - STAMPA. - 8(2):(2006), pp. 113-129. [10.2165/00148581-200608020-00004]
Valproate as a mainstay of therapy for pediatric epilepsy
GUERRINI, RENZO
2006
Abstract
This article reviews relevant pharmacologic and clinical information gathered for valproate since it was introduced into clinical practice 37 years ago and the application of this information for the treatment of childhood epilepsy. Valproate is available for oral and parenteral use. Oral forms are almost completely bioavailable but the rate of absorption varies between formulations.
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