Isoxazolidines are reductively cleaved to 1,3-aminoalcohols by reacting with Mo(CO)6 and water. Reaction conditions are simple, mild and selective giving good yields of highly functionalized products with complete retention of configuration of the stereocenters. The reduction fails when steric hindrance is experienced by the nitrogen atom.
1,3-Aminoalcohols by Reductive Cleavage of Isoxazolidines with Molybdenum Hexacarbonyl / S. CICCHI; A. GOTI; A. BRANDI; A. GUARNA; F. DE SARLO. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 31:(1990), pp. 3351-3354. [10.1016/S0040-4039(00)89062-0]
1,3-Aminoalcohols by Reductive Cleavage of Isoxazolidines with Molybdenum Hexacarbonyl
CICCHI, STEFANO;GOTI, ANDREA;BRANDI, ALBERTO;GUARNA, ANTONIO;DE SARLO, FRANCESCO
1990
Abstract
Isoxazolidines are reductively cleaved to 1,3-aminoalcohols by reacting with Mo(CO)6 and water. Reaction conditions are simple, mild and selective giving good yields of highly functionalized products with complete retention of configuration of the stereocenters. The reduction fails when steric hindrance is experienced by the nitrogen atom.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
1990_TetLett_3351.pdf
Accesso chiuso
Tipologia:
Versione finale referata (Postprint, Accepted manuscript)
Licenza:
Tutti i diritti riservati
Dimensione
3.52 MB
Formato
Adobe PDF
|
3.52 MB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
