6-O-alkyl ascorbic acid esters (ASCn) are amphiphilic mols. that behave as surfactants in aq. soln. These compds. show physico-chem. and aggregation properties that depend on the alkyl chain length, pH and temp. It must consider that ASCn have shown some phys. and rheol. properties that suggest a potential utility as drug carriers. The present paper aims to evaluate the effects of these surfactants on human erythrocyte membranes. The membrane properties studied were: osmotic resistance in hypotonic media, shape transformation, and vesicle release at lytic concn. According to our results, all properties depended on the length of the hydrophobic chain and they did not evolve monotonically. Finally, the study of ASCn interaction with erythrocyte membrane allowed us to postulate the crucial influence that the mol. structure exerts upon the manner in which amphiphiles interact with biol. membranes and the effects involved in them.
Effect of ascorbic acid based amphiphiles on human erythrocytes membrane / Rasia, M.; Spengler, M. I.; Palma, S.; Manzo, R.; LO NOSTRO, Pierandrea; Allemandi, D.. - In: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION. - ISSN 1386-0291. - STAMPA. - 36:(2007), pp. 133-140.
Effect of ascorbic acid based amphiphiles on human erythrocytes membrane
LO NOSTRO, PIERANDREA;
2007
Abstract
6-O-alkyl ascorbic acid esters (ASCn) are amphiphilic mols. that behave as surfactants in aq. soln. These compds. show physico-chem. and aggregation properties that depend on the alkyl chain length, pH and temp. It must consider that ASCn have shown some phys. and rheol. properties that suggest a potential utility as drug carriers. The present paper aims to evaluate the effects of these surfactants on human erythrocyte membranes. The membrane properties studied were: osmotic resistance in hypotonic media, shape transformation, and vesicle release at lytic concn. According to our results, all properties depended on the length of the hydrophobic chain and they did not evolve monotonically. Finally, the study of ASCn interaction with erythrocyte membrane allowed us to postulate the crucial influence that the mol. structure exerts upon the manner in which amphiphiles interact with biol. membranes and the effects involved in them.File | Dimensione | Formato | |
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