The human tachykinin NK-2 (hNK-2) receptor is considered a promising target for relevant pathologies at the respiratory, gastrointestinal and genitourinary level. With the aim of reducing the complexity of existing peptide antagonists, two series of hNK-2 receptor antagonists were designed, with the support of modelling, and synthesized. The X-ray structure determination of two compounds, each belonging to one of the two series, allowed the experimental validation of the initial rationale. In addition, it has been found that the two series share a -turn structure, a key feature for binding the hNK-2 receptor.

New monocyclic and acyclic hNK-2 antagonists retaining the beta -turn feature. X-ray and molecular modelling studies / M. Altamura; P. Dapporto; V. Fedi; A. Giolitti; A. Guerri; A. Guidi; C. A. Maggi; P. Paoli; P. Rossi. - In: ACTA CRYSTALLOGRAPHICA. SECTION B, STRUCTURAL SCIENCE. - ISSN 0108-7681. - STAMPA. - B62:(2006), pp. 889-896. [10.1107/S0108768106018167]

New monocyclic and acyclic hNK-2 antagonists retaining the beta -turn feature. X-ray and molecular modelling studies

DAPPORTO, PAOLO;GUERRI, ANNALISA;PAOLI, PAOLA;ROSSI, PATRIZIA
2006

Abstract

The human tachykinin NK-2 (hNK-2) receptor is considered a promising target for relevant pathologies at the respiratory, gastrointestinal and genitourinary level. With the aim of reducing the complexity of existing peptide antagonists, two series of hNK-2 receptor antagonists were designed, with the support of modelling, and synthesized. The X-ray structure determination of two compounds, each belonging to one of the two series, allowed the experimental validation of the initial rationale. In addition, it has been found that the two series share a -turn structure, a key feature for binding the hNK-2 receptor.
2006
B62
889
896
M. Altamura; P. Dapporto; V. Fedi; A. Giolitti; A. Guerri; A. Guidi; C. A. Maggi; P. Paoli; P. Rossi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/324801
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