The septum of male Wistar rats was injected with synthetic beta-amyloid fragments, beta 12-28, beta 25-35 and beta 1-40, and hippocampal acetylcholine (ACh) release was evaluated by transversal microdialysis. A marked decrease in basal and K(+)-evoked ACh release was found 7 or 21 days after injection of 5 nmol of beta 12-28 and beta 25-35, or 3 nmol of beta 1-40, respectively. These data indicate that septal injection of beta-amyloid peptides causes hypofunction of the septo-hippocampal cholinergic system.
Administration of amyloid ß-peptides into the medial septum of rats decreases acetylcholine release from hippocampus "in vivo" / E. Abe; F. Casamenti; L. Giovannelli; C. Scali; G. Pepeu.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 636:(1994), pp. 162-164.
Administration of amyloid ß-peptides into the medial septum of rats decreases acetylcholine release from hippocampus "in vivo"
CASAMENTI, FIORELLA;GIOVANNELLI, LISA;PEPEU, GIANCARLO
1994
Abstract
The septum of male Wistar rats was injected with synthetic beta-amyloid fragments, beta 12-28, beta 25-35 and beta 1-40, and hippocampal acetylcholine (ACh) release was evaluated by transversal microdialysis. A marked decrease in basal and K(+)-evoked ACh release was found 7 or 21 days after injection of 5 nmol of beta 12-28 and beta 25-35, or 3 nmol of beta 1-40, respectively. These data indicate that septal injection of beta-amyloid peptides causes hypofunction of the septo-hippocampal cholinergic system.
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