The influence on drug release of cyclodextrin incorporation into theophylline polymeric matrix tablets based on hydrophilic Eudragit® polymers has been investigated. Eudragit® RLPO and RSPO types, both insoluble but dispersible in water, were used to prepare tablets by direct compression. The drug was mixed with the polymer, alone or as coevaporated product with cyclodextrin. Both natural (β- and γ-) and hydrophilic derivative (hydroxypropyl, hydroxyethyl and methyl-β- and hydroxypropyl-γ-) cyclodextrins were tested, to evaluate the role of the cyclodextrin type. All tablets were coated with Eudragit®, a pH dependent polymer, to obtain gastro-resistance.
120) Effect of cyclodextrin complexation on theophylline release from coated polymeric matrix tablets / P. Mura; A.L. Ceballos; M. Cirri; F. Maestrelli. - STAMPA. - (2004), pp. 819-822. (Intervento presentato al convegno 12th International Cyclodextrin Symposium tenutosi a Montpellier nel 16-19/05/2004).
120) Effect of cyclodextrin complexation on theophylline release from coated polymeric matrix tablets
MURA, PAOLA ANGELA;CIRRI, MARZIA;MAESTRELLI, FRANCESCA
2004
Abstract
The influence on drug release of cyclodextrin incorporation into theophylline polymeric matrix tablets based on hydrophilic Eudragit® polymers has been investigated. Eudragit® RLPO and RSPO types, both insoluble but dispersible in water, were used to prepare tablets by direct compression. The drug was mixed with the polymer, alone or as coevaporated product with cyclodextrin. Both natural (β- and γ-) and hydrophilic derivative (hydroxypropyl, hydroxyethyl and methyl-β- and hydroxypropyl-γ-) cyclodextrins were tested, to evaluate the role of the cyclodextrin type. All tablets were coated with Eudragit®, a pH dependent polymer, to obtain gastro-resistance.
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