Calcium binding and release by sarcoplasmic reticulum vesicles of guinea pig heart were studied by means of a dialysis apparatus and analyzed with a model of three closed compartments. The rate constants of calcium binding were increased by taurine, and this effect was dose-related, whereas calcium efflux rate constants were very near to 0 in control experiments and were not effected by taurine. Taurine therefore increased the calcium content of sarcoplasmic vesicles and decreased the calcium concentration of the medium. beta-Alanine had no action on calcium fluxes.
The effect of taurine on calcium exchange of sarcoplasmic reticulum of guinea pig heart studied by means of dialysis kinetics / P. Dolara; A. Agresti; A. Giotti; E. Sorace. - In: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. - ISSN 0008-4212. - STAMPA. - 54:(1976), pp. 529-533.
The effect of taurine on calcium exchange of sarcoplasmic reticulum of guinea pig heart studied by means of dialysis kinetics.
DOLARA, PIERO;GIOTTI, ALBERTO;
1976
Abstract
Calcium binding and release by sarcoplasmic reticulum vesicles of guinea pig heart were studied by means of a dialysis apparatus and analyzed with a model of three closed compartments. The rate constants of calcium binding were increased by taurine, and this effect was dose-related, whereas calcium efflux rate constants were very near to 0 in control experiments and were not effected by taurine. Taurine therefore increased the calcium content of sarcoplasmic vesicles and decreased the calcium concentration of the medium. beta-Alanine had no action on calcium fluxes.
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