Atherosclerotic lesions are infiltrated by macrophages and T lymphocytes, potentially reactive to pathogens. We studied in vivo activated T lymphocytes that infiltrate atherosclerotic plaques of Helicobacter pylori-infected patients with or without anti-Chlamydia pneumoniae antibodies. In all atherosclerotic lesions, T helper type 1 (Th1) cells were predominant. C. pneumoniae-specific T cells were detected only in the plaques of anti-C. pneumoniae seropositive patients, whereas H. pylori-specific T cells were found in the gastric mucosa but not in the plaques of the same patients. Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition.

T helper type-1 lymphocyte-drive inflammation in human atherosclerotic lesions / BENAGIANO M.; AZZURRI A.; CIERVO A.; AMEDEI A.; TAMBURINI C.; FERRARI M.; TELFORD J.L.; BALDARI C.T.; ROMAGNANI S.; CASSONE A.; D'ELIOS M.M.; DEL PRETE G.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 100:(2003), pp. 6658-6663. [10.1073/pnas.1135726100]

T helper type-1 lymphocyte-drive inflammation in human atherosclerotic lesions.

AMEDEI, AMEDEO;ROMAGNANI, SERGIO;D'ELIOS, MARIO MILCO;DEL PRETE, GIANFRANCO
2003

Abstract

Atherosclerotic lesions are infiltrated by macrophages and T lymphocytes, potentially reactive to pathogens. We studied in vivo activated T lymphocytes that infiltrate atherosclerotic plaques of Helicobacter pylori-infected patients with or without anti-Chlamydia pneumoniae antibodies. In all atherosclerotic lesions, T helper type 1 (Th1) cells were predominant. C. pneumoniae-specific T cells were detected only in the plaques of anti-C. pneumoniae seropositive patients, whereas H. pylori-specific T cells were found in the gastric mucosa but not in the plaques of the same patients. Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition.
2003
100
6658
6663
BENAGIANO M.; AZZURRI A.; CIERVO A.; AMEDEI A.; TAMBURINI C.; FERRARI M.; TELFORD J.L.; BALDARI C.T.; ROMAGNANI S.; CASSONE A.; D'ELIOS M.M.; DEL PRETE G.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/333370
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