Monoamine oxidase (MAO) and benzylamine oxidases (Bz-SSAO) of rat white adipocytes, deaminating benzylamine and tyramine produce hydrogen peroxide at different cellular levels. The peroxide produced by their activity has a very short half-life in adipocyte suspension. The addition of a catalase inhibitor allows for the recovery of the intact peroxide within the first 10-min of its production. Thus, benzylamine and tyramine-dependent peroxide recovery is different, suggesting that the fate of the peroxide produced by the two amine oxidases might be different depending on the cellular site of its production
Possible different fates for the hydrogen peroxide produced by rat white adipocyte amine oxidases / Raimondi L; Banchelli G; Sgromo L; Pirisino R. - In: NEUROBIOLOGY. - ISSN 1216-8068. - STAMPA. - 8(1):(2000), pp. 99-107. (Intervento presentato al convegno International Amine oxidase Workshop).
Possible different fates for the hydrogen peroxide produced by rat white adipocyte amine oxidases
RAIMONDI, LAURA;BANCHELLI, MARIA GRAZIA;PIRISINO, RENATO GIOVANNI PAOLO
2000
Abstract
Monoamine oxidase (MAO) and benzylamine oxidases (Bz-SSAO) of rat white adipocytes, deaminating benzylamine and tyramine produce hydrogen peroxide at different cellular levels. The peroxide produced by their activity has a very short half-life in adipocyte suspension. The addition of a catalase inhibitor allows for the recovery of the intact peroxide within the first 10-min of its production. Thus, benzylamine and tyramine-dependent peroxide recovery is different, suggesting that the fate of the peroxide produced by the two amine oxidases might be different depending on the cellular site of its production
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