CuI-catalyzed azide-alkyne 1,3-dipolar Huisgen’s cycloaddition (CuAAC) is a click reaction that has drawn a lot of attention, in general, and in the field of peptide and protein sciences, in particular. Among several reported applications, the preparation of novel heterodetic cyclopeptides by an intramolecular side chain-to-side chain CuAAC, forming a 1,4- disubstituted[1,2,3]triazolyl-containing bridge, is of great interest. Herein, we provide a detailed protocol for the syntheses of model heterodetic cyclopeptides as a rototypical intramolecular CuAAC, using as amodel a sequence derived from parathyroid hormone-related protein.

Side chain-to-side chain cyclization by click reaction / A. Le Chevalier-Isaad; A.M. Papini; M. Chorev; P. Rovero. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - STAMPA. - 15:(2009), pp. 451-454. [10.1002/psc.1141]

Side chain-to-side chain cyclization by click reaction.

PAPINI, ANNA MARIA;ROVERO, PAOLO
2009

Abstract

CuI-catalyzed azide-alkyne 1,3-dipolar Huisgen’s cycloaddition (CuAAC) is a click reaction that has drawn a lot of attention, in general, and in the field of peptide and protein sciences, in particular. Among several reported applications, the preparation of novel heterodetic cyclopeptides by an intramolecular side chain-to-side chain CuAAC, forming a 1,4- disubstituted[1,2,3]triazolyl-containing bridge, is of great interest. Herein, we provide a detailed protocol for the syntheses of model heterodetic cyclopeptides as a rototypical intramolecular CuAAC, using as amodel a sequence derived from parathyroid hormone-related protein.
2009
15
451
454
A. Le Chevalier-Isaad; A.M. Papini; M. Chorev; P. Rovero
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/364195
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