Recent advances in solution NMR: fast methods and heteronuclear direct detection

NMR spectroscopy for the molecular life sciences: Two areas of recent active research [fast methods and direct detection of low-γ nuclei (see schematic)] are reviewed herein. These are powerful new tools for structural characterization of short-lived molecules, large and intrinsically unstructured proteins, paramagnetic systems, as well as for the study of molecular kinetic processes at atomic resolution.