Objectives. The aim of our study was to investigate the prognostic impact of aPL in paediatric onset systemic lupus erythematosus (p-SLE). Methods. This retrospective study included 56 patients with p-SLE. 2-test, Fisher’s exact test, incidence rate ratio and Kaplan–Meier survival curves were used to compare aPL-positive and aPL-negative patients considering the value of SDI (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for SLE) at the end of follow-up, the occurrence of thromboses, organ system involvements and need for immunosuppressive treatment in addition to corticosteroids. Results. Anti-cardiolipin antibodies and lupus anticoagulants were detected in 27 (49%) and 19 (35%) patients, respectively. These aPL were frequently transient or intermittent (10 and 15 cases, respectively), and only rarely persistent over time (five cases). The risk of thrombosis was significantly higher (odds ratio¼6.42) and occurred earlier in the presence of aPL, especially if aPL were persistent (P<0.05). The association between aPL and neurological, renal, haematological manifestations or need for immunosuppressive treatment was not statistically significant. After a mean follow-up of 7.2 yrs, 30 patients (54.5%) had an SDI score 1. The risk of damage (SDI1) in aPL-positive patients was three times higher than in aPL-negative patients (P<0.05). Four of the six fatal cases occurred in the aPL-positive group. Conclusions. The presence of aPL in p-SLE could represent not only a risk factor for thrombosis but also a poor prognostic factor overall.

Paediatric systemic lupus erythematosus: prognostic impact of antiphospholipid antibodies / Descloux E; Durieu I; Cochat P; Vital Durand D; Ninet J; Fabien N; Cimaz R.. - In: RHEUMATOLOGY. - ISSN 1462-0324. - STAMPA. - 47:(2008), pp. 183-187. [10.1093/rheumatology/kem335]

Paediatric systemic lupus erythematosus: prognostic impact of antiphospholipid antibodies.

CIMAZ, ROLANDO
2008

Abstract

Objectives. The aim of our study was to investigate the prognostic impact of aPL in paediatric onset systemic lupus erythematosus (p-SLE). Methods. This retrospective study included 56 patients with p-SLE. 2-test, Fisher’s exact test, incidence rate ratio and Kaplan–Meier survival curves were used to compare aPL-positive and aPL-negative patients considering the value of SDI (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for SLE) at the end of follow-up, the occurrence of thromboses, organ system involvements and need for immunosuppressive treatment in addition to corticosteroids. Results. Anti-cardiolipin antibodies and lupus anticoagulants were detected in 27 (49%) and 19 (35%) patients, respectively. These aPL were frequently transient or intermittent (10 and 15 cases, respectively), and only rarely persistent over time (five cases). The risk of thrombosis was significantly higher (odds ratio¼6.42) and occurred earlier in the presence of aPL, especially if aPL were persistent (P<0.05). The association between aPL and neurological, renal, haematological manifestations or need for immunosuppressive treatment was not statistically significant. After a mean follow-up of 7.2 yrs, 30 patients (54.5%) had an SDI score 1. The risk of damage (SDI1) in aPL-positive patients was three times higher than in aPL-negative patients (P<0.05). Four of the six fatal cases occurred in the aPL-positive group. Conclusions. The presence of aPL in p-SLE could represent not only a risk factor for thrombosis but also a poor prognostic factor overall.
2008
47
183
187
Descloux E; Durieu I; Cochat P; Vital Durand D; Ninet J; Fabien N; Cimaz R.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/390371
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