Background and purpose: Post-operative radiotherapy (PORT) in radically resected non-small cell lung cancer (NSCLC) has the aim to reduce loco regional recurrence and to improve overall survival. PORT has been evaluated in several trials but indication to post-operative treatment in N2 patients is still debated. Material and methods: We retrospectively analyzed 175 patients treated at University of Florence between 1988 and 2004 with completely resected NSCLC stages IIIA–IIIB, N2 disease. Surgery consisted in a lobectomy in 58.9% and in a bi-lobectomy or in a pneumonectomy in 41.1% of patients. One hundred and nineteen patients underwent PORT and 56 patients did not receive PORT (no-PORT). Results: At a median follow-up of 27.6 months (range 4–233 months), we found a significant reduction in local recurrence (LR) in PORT group (log-rank test p = 0.015; HR: 0.45; 95%CI: 0.24–0.87). No statistical difference were found in terms of overall survival (OS) (log-rank test p = 0.92). Concerning other prognostic factors, male sex emerged as statistically significant (HR:4.33;1.04–18.02) on local progression free survival (LPFS) at univariate analysis. Acute and long-term toxicity was mild. Conclusion: Our retrospective analysis showed that PORT may improve local disease control in N2 NSCLC patients with an acceptable treatment-related toxicity.

Post-operative radiotherapy in N2 non-small cell lung cancer: a retrospective analysis of 175 patients / Scotti V; Meattini I; Saieva C; Agresti B; de Luca Cardillo C; Bastiani P; Livi L; Mangoni M; Di Cataldo V; Marrazzo L; Rampini A; Cipressi S; Bruni A; Santini P; Biti G. - In: RADIOTHERAPY AND ONCOLOGY. - ISSN 0167-8140. - STAMPA. - 96:(2010), pp. 84-88. [10.1016/j.radonc.2010.05.010]

Post-operative radiotherapy in N2 non-small cell lung cancer: a retrospective analysis of 175 patients.

SCOTTI, VIERI;MEATTINI, ICRO;LIVI, LORENZO;MANGONI, MONICA;MARRAZZO, LIVIA;BITI, GIAMPAOLO
2010

Abstract

Background and purpose: Post-operative radiotherapy (PORT) in radically resected non-small cell lung cancer (NSCLC) has the aim to reduce loco regional recurrence and to improve overall survival. PORT has been evaluated in several trials but indication to post-operative treatment in N2 patients is still debated. Material and methods: We retrospectively analyzed 175 patients treated at University of Florence between 1988 and 2004 with completely resected NSCLC stages IIIA–IIIB, N2 disease. Surgery consisted in a lobectomy in 58.9% and in a bi-lobectomy or in a pneumonectomy in 41.1% of patients. One hundred and nineteen patients underwent PORT and 56 patients did not receive PORT (no-PORT). Results: At a median follow-up of 27.6 months (range 4–233 months), we found a significant reduction in local recurrence (LR) in PORT group (log-rank test p = 0.015; HR: 0.45; 95%CI: 0.24–0.87). No statistical difference were found in terms of overall survival (OS) (log-rank test p = 0.92). Concerning other prognostic factors, male sex emerged as statistically significant (HR:4.33;1.04–18.02) on local progression free survival (LPFS) at univariate analysis. Acute and long-term toxicity was mild. Conclusion: Our retrospective analysis showed that PORT may improve local disease control in N2 NSCLC patients with an acceptable treatment-related toxicity.
2010
96
84
88
Scotti V; Meattini I; Saieva C; Agresti B; de Luca Cardillo C; Bastiani P; Livi L; Mangoni M; Di Cataldo V; Marrazzo L; Rampini A; Cipressi S; Bruni A; Santini P; Biti G
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/395778
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