Abstract A role for neurotrophins in regulating cortical developmental plasticity has clearly emerged in these last years. In this review we first present a summary of the early data on the action of NGF in visual cortical development and plasticity in the rat and of the actions of the other neurotrophins in the visual cortex of other mammals. In addition, in order to clarify the differences in the results obtained with the various neurotrophins in different animal preparations we also report new data on the action of NGF, BDNF, NT3 and NT4 in the same preparation, namely the visual cortex of the rat. We discuss old and new results in a physiological model where different neurotrophins play different roles in regulating visual cortical development and plasticity by acting on different neural targets, such as LGN afferents, intracortical circuitry and subcortical afferents and propose a tentative scheme summarizing these actions.

Role of neurotrophins in neural plasticity: what we learn from the visual cortex / Berardi N; Lodovichi C; Caleo M; Pizzorusso T; Maffei L.. - In: RESTORATIVE NEUROLOGY AND NEUROSCIENCE. - ISSN 0922-6028. - STAMPA. - 15:(1999), pp. 125-136.

Role of neurotrophins in neural plasticity: what we learn from the visual cortex.

BERARDI, NICOLETTA;PIZZORUSSO, TOMMASO;
1999

Abstract

Abstract A role for neurotrophins in regulating cortical developmental plasticity has clearly emerged in these last years. In this review we first present a summary of the early data on the action of NGF in visual cortical development and plasticity in the rat and of the actions of the other neurotrophins in the visual cortex of other mammals. In addition, in order to clarify the differences in the results obtained with the various neurotrophins in different animal preparations we also report new data on the action of NGF, BDNF, NT3 and NT4 in the same preparation, namely the visual cortex of the rat. We discuss old and new results in a physiological model where different neurotrophins play different roles in regulating visual cortical development and plasticity by acting on different neural targets, such as LGN afferents, intracortical circuitry and subcortical afferents and propose a tentative scheme summarizing these actions.
1999
15
125
136
Berardi N; Lodovichi C; Caleo M; Pizzorusso T; Maffei L.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/395950
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