Background: As a part of the National Plan for Measles and Congenital Rubella Elimination, a catch-up campaign targeting children aged 7-14 years with Measles-Mumps-Rubella (MMR) vaccine was conducted during 2004-05 in Tuscany, Central Italy. Methods: To assess the profile of measles and rubella susceptibility, immunoglobulin G antibodies against measles (945 subjects) and rubella (1110 subjects) were detected using two commercial enzyme-linked immunosorbent assay tests in sera from a population aged 1-49 years. Results: Overall immunity towards measles increased in the last years, but the WHO-Euro recommended threshold of susceptibility for elimination was attained only in 2- to 4-year-olds. All fertile women up to 29 years had rates of susceptibility clearly higher than those required by WHO-Euro (5%) to eliminate congenital rubella. Despite the reduction of susceptibility among subjects targeted by the catch-up campaign, continuous efforts to increase immunization coverage are needed to eliminate measles and rubella circulation. Our results are predictive of a high chance of measles and rubella outbreaks because of the accumulation of susceptible individuals. Conclusion: Additional catch-up vaccination strategies targeting the adult population (particularly fertile women) are strongly needed to eliminate the risk of measles and congenital rubella syndrome for future generations.

Progress towards measles and rubella elimination in Tuscany,l Italy: the role of population seroepidemiological profile / Bechini A; Boccalini S; Tiscione E; Pesavento G; Mannelli F; Peruzzi M; Rapi S; Mercurio S; Paolo Bonanni P. - In: EUROPEAN JOURNAL OF PUBLIC HEALTH. - ISSN 1101-1262. - STAMPA. - 22:(2012), pp. 133-139. [10.1093/eurpub/ckq134]

Progress towards measles and rubella elimination in Tuscany,l Italy: the role of population seroepidemiological profile

BECHINI, ANGELA;BOCCALINI, SARA;TISCIONE, EMILIA;PESAVENTO, GIOVANNA;MANNELLI, FRANCESCO;PERUZZI, MARTA;BONANNI, PAOLO
2012

Abstract

Background: As a part of the National Plan for Measles and Congenital Rubella Elimination, a catch-up campaign targeting children aged 7-14 years with Measles-Mumps-Rubella (MMR) vaccine was conducted during 2004-05 in Tuscany, Central Italy. Methods: To assess the profile of measles and rubella susceptibility, immunoglobulin G antibodies against measles (945 subjects) and rubella (1110 subjects) were detected using two commercial enzyme-linked immunosorbent assay tests in sera from a population aged 1-49 years. Results: Overall immunity towards measles increased in the last years, but the WHO-Euro recommended threshold of susceptibility for elimination was attained only in 2- to 4-year-olds. All fertile women up to 29 years had rates of susceptibility clearly higher than those required by WHO-Euro (5%) to eliminate congenital rubella. Despite the reduction of susceptibility among subjects targeted by the catch-up campaign, continuous efforts to increase immunization coverage are needed to eliminate measles and rubella circulation. Our results are predictive of a high chance of measles and rubella outbreaks because of the accumulation of susceptible individuals. Conclusion: Additional catch-up vaccination strategies targeting the adult population (particularly fertile women) are strongly needed to eliminate the risk of measles and congenital rubella syndrome for future generations.
2012
22
133
139
Bechini A; Boccalini S; Tiscione E; Pesavento G; Mannelli F; Peruzzi M; Rapi S; Mercurio S; Paolo Bonanni P
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/396966
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